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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Inhibitor of nuclear factor kappa-B kinase subunit beta
Summary
- UniProt ID
- O14920
- Gene Symbol
-
- IKBKB
- IKKB
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Acetylation
- Alternative splicing
- Cytoplasm
- Direct protein sequencing
- Disease variant
- Host-virus interaction
- Hydroxylation
- Isopeptide bond
- Membrane
- Nucleus
- Phosphoprotein
- Reference proteome
- S-nitrosylation
- SCID
- Serine/threonine-protein kinase
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| cytoplasm |
| cytosol |
| nucleus |
| cytoplasmic side of plasma membrane |
| membrane raft |
| IkappaB kinase complex |
| CD40 receptor complex |
Sequence
MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 471 |
|
|||
| 733 |
|
|||
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| IkBA variant leads to EDA-ID | Homo sapiens |
| Interleukin-1 signaling | Homo sapiens |
| MAP3K8 (TPL2)-dependent MAPK1/3 activation | Homo sapiens |
| NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | Homo sapiens |
| NF-kB is activated and signals survival | Homo sapiens |
| NOD1/2 Signaling Pathway | Homo sapiens |
| PKR-mediated signaling | Homo sapiens |
| RIP-mediated NFkB activation via ZBP1 | Homo sapiens |
| Regulation of NF-kappa B signaling | Homo sapiens |
| Regulation of TNFR1 signaling | Homo sapiens |
