NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
FADDviral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADDRIP1viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVSviral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-479), CASP10(1-521)CASP8(1-479), CASP10(1-521)viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521)CASP8(385-479)Casp-10 p10CASP8(375-384)CASP10viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-216), CASP10(1-219)CASP8viral dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomaindsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain:IKK complexIKK complex
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025