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E3 ubiquitin-protein ligase RNF135

Summary

UniProt ID

Q8IUD6

Gene Symbol

RNF135

Organism

Homo sapiens (human)

External Links

GlyGen: Q8IUD6
The O-GlcNAc Database: Q8IUD6
O-GlcNAcAtlas: Q8IUD6

Annotation

Keyword

3D-structure
Alternative splicing
Coiled coil
Cytoplasm
Disease variant
Innate immunity
Reference proteome
Transferase
Ubl conjugation pathway
Zinc-finger

Gene Ontology (GO)

Displaying **all 10** entries
GO Term
innate immune response
regulation of innate immune response
free ubiquitin chain polymerization
protein polyubiquitination
protein ubiquitination
positive regulation of interferon-beta production
RIG-I signaling pathway
protein homooligomerization
antiviral innate immune response
protein K63-linked ubiquitination

Displaying **all 4** entries
GO Term
cytosol
cytoplasm
cytoplasmic stress granule
ribonucleoprotein complex

Displaying **all 6** entries
GO Term
metal ion binding
RIG-I binding
ubiquitin-protein transferase activity
identical protein binding
ubiquitin protein ligase activity
ribonucleoprotein complex binding

Annotation information from UniProt.

Sequence

MAGLGLGSAVPVWLAEDDLGCIICQGLLDWPATLPCGHSFCRHCLEALWGARDARRWACPTCRQGAAQQPHLRKNTLLQDLADKYRRAAREIQAGSDPAHCPCPGSSSLSSAAARPRRRPELQRVAVEKSITEVAQELTELVEHLVDIVRSLQNQRPLSESGPDNELSILGKAFSSGVDLSMASPKLVTSDTAAGKIRDILHDLEEIQEKLQESVTWKEAPEAQMQGELLEAPSSSSCPLPDQSHPALRRASRFAQWAIHPTFNLKSLSCSLEVSKDSRTVTVSHRPQPYRWSCERFSTSQVLCSQALSSGKHYWEVDTRNCSHWAVGVASWEMSRDQVLGRTMDSCCVEWKGTSQLSAWHMVKETVLGSDRPGVVGIWLNLEEGKLAFYSVDNQEKLLYECTISASSPLYPAFWLYGLHPGNYLIIKQVKV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
190			G49108TO	GlyGen The O-GlcNAc Database
278			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 8** entries
Pathway Name	Organism
DDX58/IFIH1-mediated induction of interferon-alpha/beta	Homo sapiens
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	Homo sapiens
Negative regulators of RIG-I/MDA5 signaling	Homo sapiens
Ovarian tumor domain proteases	Homo sapiens
SARS-CoV-2 activates/modulates innate and adaptive immune responses	Homo sapiens
TRAF3-dependent IRF activation pathway	Homo sapiens
TRAF6 mediated IRF7 activation	Homo sapiens
TRAF6 mediated NF-kB activation	Homo sapiens