TRAF3-dependent IRF activation pathway

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVSviral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3K63polyUb-TRAF3dsRNA:RIG-1/MDA5:IPS-1:Ub-TRAF3:TBK1/IKKidsRNA:RIG-1/MDA5:IPS-1:Ub-TRAF3:2xTBK1/IKKiTBK1, IKBKEIRF3,IRF7dsRNA:RIG-1/MDA5:IPS-1:Ub-TRAF3:TBK1,IKBKE:IRF3,IRF7dsRNA:RIG-1/MDA5:IPS-1:Ub-TRAF3:2x(TBK1/IKBKE)phosphorylated IRF3/IRF7ATPADPp-2S-IRF7:p-2S-IRF7p-T,4S-IRF3:p-T,4S-IRF3IRF3-P:IRF7-PIRF3-P:IRF7-Pp-T,4S-IRF3:p-T,4S-IRF32xp-S477,S479-IRF7IFNB1 geneIRF3 bound to IFN-beta promoterIRF3-P dimer:CBP/p300IFNB1CBP/p300TBK1/IKKi:SIKE1SIKE1
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025