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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Klotho
Summary
- UniProt ID
- O35082
- Gene Symbol
-
- Kl
- Organism
- Mus musculus (house mouse)
External Links
- GlycoProtDB
- GPDB0003079
- PubChem
- O35082
Annotation
- Keyword
-
- Alternative splicing
- Cell membrane
- Glycoprotein
- Glycosidase
- Reference proteome
- Repeat
- Secreted
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway |
| response to vitamin D |
| GO Term |
|---|
| apical plasma membrane |
| extracellular region |
| membrane |
| GO Term |
|---|
| fibroblast growth factor binding |
| beta-glucuronidase activity |
| fibroblast growth factor receptor binding |
Sequence
MLARAPPRRPPRLVLLRLLLLHLLLLALRARCLSAEPGQGAQTWARFARAPAPEAAGLLHDTFPDGFLWAVGSAAYQTEGGWRQHGKGASIWDTFTHHSGAAPSDSPIVVAPSGAPSPPLSSTGDVASDSYNNVYRDTEGLRELGVTHYRFSISWARVLPNGTAGTPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDTYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGVRGSSRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGRVSIALSSHWINPRRMTDYNIRECQKSLDFVLGWFAKPIFIDGDYPESMKNNLSSLLPDFTESEKRLIRGTADFFALSFGPTLSFQLLDPNMKFRQLESPNLRQLLSWIDLEYNHPPIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLKAIRLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKELLPKSSALFYQKLIEDNGFPPLPENQPLEGTFPCDFAWGVVDNYVQVDTTLSQFTDPNVYLWDVHHSKRLIKVDGVVAKKRKPYCVDFSAIRPQITLLREMRVTHFRFSLDWALILPLGNQTQVNHTVLHFYRCMISELVHANITPVVALWQPAAPHQGLPHALAKHGAWENPHTALAFADYANLCFKELGHWVNLWITMNEPNTRNMTYRAGHHLLRAHALAWHLYDDKFRAAQKGKISIALQADWIEPACPFSQNDKEVAERVLEFDIGWLAEPIFGSGDYPRVMRDWLNQKNNFLLPYFTEDEKKLVRGSFDFLAVSHYTTILVDWEKEDPMKYNDYLEVQEMTDITWLNSPSQVAVVPWGLRKVLNWLRFKYGDLPMYVTANGIDDDPHAEQDSLRIYYIKNYVNEALKAYVLDDINLCGYFAYSLSDRSAPKSGFYRYAANQFEPKPSMKHYRKIIDSNGFLGSGTLGRFCPEEYTVCTECGFFQTRKSLLVFISFLVFTFIISLALIFHYSKKGQRSYK
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 161 | N-linked (GlcNAc...) asparagine |
|
||
| 285 | N-linked (GlcNAc...) asparagine |
|
||
| 346 | N-linked (GlcNAc...) asparagine |
|
||
| 609 | N-linked (GlcNAc...) asparagine |
|
||
| 614 | N-linked (GlcNAc...) asparagine |
|
||
| 696 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Downstream signaling of activated FGFR1 | Mus musculus |
| FGFR1c and Klotho ligand binding and activation | Mus musculus |
| FRS-mediated FGFR1 signaling | Mus musculus |
| Negative regulation of FGFR1 signaling | Mus musculus |
| PI-3K cascade:FGFR1 | Mus musculus |
| PI3K Cascade | Mus musculus |
| PI3K/AKT Signaling | Mus musculus |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | Mus musculus |
| Phospholipase C-mediated cascade: FGFR1 | Mus musculus |
| RAF/MAP kinase cascade | Mus musculus |
