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Nuclear factor erythroid 2-related factor 2

Summary

UniProt ID

O54968

Gene Symbol

Nfe2l2
Nrf2

Gene ID

83619

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: O54968
Re-Glyco: O54968

Annotation

Keyword

Acetylation
Activator
Alternative splicing
Cytoplasm
DNA-binding
Glycation
Nucleus
Phosphoprotein
Reference proteome
Transcription regulation
Ubl conjugation

Gene Ontology (GO)

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GO Term
RNA polymerase II transcription regulator complex
chromatin
nucleus
cytoplasm
plasma membrane
protein-DNA complex
nucleoplasm
Golgi apparatus
cytosol
centrosome

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

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GO Term
proteasomal ubiquitin-independent protein catabolic process
PERK-mediated unfolded protein response
aflatoxin catabolic process
positive regulation of reactive oxygen species metabolic process
inflammatory response
positive regulation of gene expression
positive regulation of blood coagulation
regulation of innate immune response
positive regulation of angiogenesis
regulation of embryonic development

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GO Term
RNA polymerase II cis-regulatory region sequence-specific DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
transcription coregulator binding
DNA-binding transcription activator activity, RNA polymerase II-specific
DNA binding
DNA-binding transcription factor activity
protein domain specific binding
ubiquitin protein ligase binding
sequence-specific DNA binding
RNA polymerase II-specific DNA-binding transcription factor binding

Annotation information from UniProt.

Sequence

MMDLELPPPGLQSQQDMDLIDILWRQDIDLGVSREVFDFSQRQKDYELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQTDTSGSVSYSQVAHIPKQDALYFEDCMQLLAETFPFVDDHEVSSPTFQSLALDIPSHVESSVFTTPDQAQSLDSSLETAMTDLSSIQQDMEQVWQELFSIPELQCLNTENKQQAETTTVPSPEATLTEMDSNYHFYSSIPSLEKEVDSCSPHFLHGFEDSFSSILSTDDASQLNSLDSNPTLNTDFGDEFYSAFLAEPSGGGSMPSSAAISQSLSELLGGPIEGCDLSLCKAFNQKHTEGTVEFNDSDSGISLNTSPSRASPEHSVESSIYGDPPPGFSDSEMEELDSAPGSVKQNGPKAQPTHSSGDTVQPLSPAQGHSAAVHESQCENTTKKEVPVSPGHQKVPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVDDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLGHLKDEREKLLREKGENDRNLHLLKRKLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKPDTKKN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	Source
461	N-linked (Glc) (glycation) lysine	UniProt
471	N-linked (Glc) (glycation) lysine	UniProt
486	N-linked (Glc) (glycation) lysine	UniProt
498	N-linked (Glc) (glycation) arginine	UniProt
568	N-linked (Glc) (glycation) arginine	UniProt
573	N-linked (Glc) (glycation) lysine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	Rattus norvegicus
KEAP1-NFE2L2 pathway	Rattus norvegicus
Neddylation	Rattus norvegicus
Nuclear events mediated by NFE2L2	Rattus norvegicus

Disease

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0080208	metabolic dysfunction-associated steatotic liver disease	Alliance of Genome Resources
DOID:11832	visual epilepsy	Alliance of Genome Resources
DOID:3525	middle cerebral artery infarction	Alliance of Genome Resources
DOID:3770	pulmonary fibrosis	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:8947	diabetic retinopathy	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements