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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Toll-like receptor 2
Summary
- UniProt ID
- O60603
- Gene Symbol
-
- TLR2
- TIL4
- Organism
- Homo sapiens (human)
External Links
- GlyConnect
- GlyGen
- O60603
- PubChem
- O60603
- The Human Metabolome Database
- HMDBP12412
Annotation
- Keyword
-
- 3D-structure
- Cytoplasmic vesicle
- Disulfide bond
- Glycoprotein
- Inflammatory response
- Innate immunity
- Isopeptide bond
- Leucine-rich repeat
- NAD
- Receptor
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| cytoplasm |
| Golgi apparatus |
| plasma membrane |
| secretory granule membrane |
| cell projection |
| receptor complex |
| cell body |
| phagocytic vesicle membrane |
| membrane raft |
| cell surface |
Sequence
MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 114 | N-linked (GlcNAc...) asparagine |
|
||
| 199 | N-linked (GlcNAc...) asparagine | |||
| 414 | N-linked (GlcNAc...) asparagine | |||
| 442 | N-linked (GlcNAc...) asparagine |
G08146BT
G22310AV
G71146HJ
G75983OB
G45395BF
G40926MX
G83229XP
G00912UN
G25451PN
G27058EU
G45495MK
G84452RH
G70101JE
G80920RR
G62765YT
G83460ZZ
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Beta defensins | Homo sapiens |
| ER-Phagosome pathway | Homo sapiens |
| IRAK4 deficiency (TLR2/4) | Homo sapiens |
| Modulation by Mtb of host immune system | Homo sapiens |
| MyD88 deficiency (TLR2/4) | Homo sapiens |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
| RSV-host interactions | Homo sapiens |
| Regulation of TLR by endogenous ligand | Homo sapiens |
| SARS-CoV-2 activates/modulates innate and adaptive immune responses | Homo sapiens |
