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Standards Ontologies Notations
Toll-like receptor 2

Summary
UniProt ID
O60603
Gene Symbol
  • TLR2
  • TIL4
Organism
Homo sapiens (human)
External Links
GlyConnect
GlyGen
O60603
PubChem
O60603
The Human Metabolome Database
HMDBP12412
Annotation
Keyword
  • 3D-structure
  • Cytoplasmic vesicle
  • Disulfide bond
  • Glycoprotein
  • Inflammatory response
  • Innate immunity
  • Isopeptide bond
  • Leucine-rich repeat
  • NAD
  • Receptor
  • Reference proteome
  • Repeat
  • Signal
  • Transmembrane helix
  • Ubl conjugation
Gene Ontology (GO)
Displaying entries 11 - 12 of 12 in total
GO Term
Toll-like receptor binding
triacyl lipopeptide binding
Annotation information from UniProt.
Sequence
MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKS
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 4 entries
Position Description PubMed ID GlyTouCan ID Source
114 N-linked (GlcNAc...) asparagine
199 N-linked (GlcNAc...) asparagine
414 N-linked (GlcNAc...) asparagine
442 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 1 - 10 of 12 in total
Pathway Name Organism
Beta defensins Homo sapiens
ER-Phagosome pathway Homo sapiens
IRAK4 deficiency (TLR2/4) Homo sapiens
Modulation by Mtb of host immune system Homo sapiens
MyD88 deficiency (TLR2/4) Homo sapiens
MyD88:MAL(TIRAP) cascade initiated on plasma membrane Homo sapiens
Neutrophil degranulation Homo sapiens
RSV-host interactions Homo sapiens
Regulation of TLR by endogenous ligand Homo sapiens
SARS-CoV-2 activates/modulates innate and adaptive immune responses Homo sapiens
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024