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MIRAGE
BRCA1-associated RING domain protein 1
Summary
- UniProt ID
- O70445
- Gene Symbol
-
- Bard1
- Gene ID
- 12021
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- ANK repeat
- Cytoplasm
- DNA repair
- Isopeptide bond
- Nucleus
- Phosphoprotein
- Reference proteome
- Repeat
- Transferase
- Ubl conjugation
- Ubl conjugation pathway
- Zinc-finger
- Gene Ontology (GO)
| GO Term |
|---|
| nuclear speck |
| cytoplasmic ribonucleoprotein granule |
| nucleus |
| cytoplasm |
| nuclear ubiquitin ligase complex |
| BRCA1-BARD1 complex |
| BRCA1-A complex |
| BRCA1-B complex |
| BRCA1-C complex |
| GO Term |
|---|
| metal ion binding |
| RNA binding |
| ubiquitin-protein transferase activity |
| protein homodimerization activity |
| protein heterodimerization activity |
Sequence
MPRRPPRVCSGNQPAPVPAMEPATDGLWAHSRAALARLEKLLRCSRCANILKEPVCLGGCEHIFCSGCISDCVGSGCPVCYTPAWILDLKINRQLDSMIQLSSKLQNLLHDNKDSKDNTSRASLFGDAERKKNSIKMWFSPRSKKVRYVVTKVSVQTQPQKAKDDKAQEASMYEFVSATPPVAVPKSAKTASRTSAKKHPKKSVAKINREENLRPETKDSRFDSKEELKEEKVVSCSQIPVMERPRVNGEIDLLASGSVVEPECSGSLTEVSLPLAEHIVSPDTVSKNEETPEKKVCVKDLRSGGSNGNRKGCHRPTTSTSDSCGSNIPSTSRGIGEPALLAENVVLVDCSSLPSGQLQVDVTLRRKSNASDDPLSLSPGTPPPLLNNSTHRQMMSSPSTVKLSSGMPARKRNHRGETLLHIASIKGDIPSVEYLLQNGNDPNVKDHAGWTPLHEACSHGHLKVVELLLQHNALVNTPGYQNDSPLHDAVKSGHIDIVKVLLSHGASRNAVNIFGVRPVDYTDNENIRSLLLLPEENESFSTSQCSIVNTGQRKNGPLVFIGSGLSSQQQKMLSKLETVLKAKKCMEFDSTVTHVIVPDEEAQSTLKCMLGILSGCWILKFDWVKACLDSKVREQEEKYEVPGGPQRSRLNREQLLPKLFDGCYFFLGGNFKHHPRDDLLKLIAAAGGKVLSRKPKPDSDVTQTINTVAYHAKPESDQRFCTQYIVYEDLFNCHPERVRQGKVWMAPSTWLISCIMAFELLPLDS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 326 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| G2/M DNA damage checkpoint | Mus musculus |
| HDR through Homologous Recombination (HRR) | Mus musculus |
| HDR through Single Strand Annealing (SSA) | Mus musculus |
| Homologous DNA Pairing and Strand Exchange | Mus musculus |
| Metalloprotease DUBs | Mus musculus |
| Nonhomologous End-Joining (NHEJ) | Mus musculus |
| Presynaptic phase of homologous DNA pairing and strand exchange | Mus musculus |
| Processing of DNA double-strand break ends | Mus musculus |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | Mus musculus |
| Regulation of TP53 Activity through Phosphorylation | Mus musculus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:1612 | breast cancer |
