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MIRAGE
Processing of DNA double-strand break ends

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complexUbe2iSUMO2:UBE2IDNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complexRnf168UbPIAS4P70399Babam1DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5p-5S-BRCA1:p-2T-BARD1K48PolyUb:SUMO2:K1840,p-5T-MDC1 dimerBREUBE2N:UBE2V2UIMC1Q4U2R1Q8BVE8BRCC3Q8BPZ8K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-NucleosomeRNF8:Zn2+NADRBBP8 homotetramer2'-O-acetyl-ADP-riboseAc-K-RBBP8 homotetramerNAMCCNA:p-T160-CDK2DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8ATPDNA DSBs:p-MRN:p-S327,T847-RBBP8:p-S1981,Ac-K3016-ATM:KAT5ADPDNA DSBs:p-MRN:p-S327,T847,T859-RBBP8:p-S1981,Ac-K3016-ATM:KAT5DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-BRCA1-C complexH2OdNTP3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complexEXO1,DNA2:BLM,WRN3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1Q5SXJ33' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1RPA heterotrimerRPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1ATR:ATRIPATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1RAD9:HUS1:RAD1Topbp1RAD17:RFCRhno1ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1TIMELESS:TIPINATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1Q80YR7CHEK1O35280p-RPA heterotrimerPi
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
Displaying entries 1 - 10 of 27 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O09053 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
  • Wrn
 view
O70445 BRCA1-associated RING domain protein 1
  • Bard1
 view
P0CG49 Polyubiquitin-B
  • Ubb
 view
P10853 Histone H2B type 1-F/J/L
  • H2b-f
  • H2b-j
  • H2b-l
  • H2b-n
  • H2bc11
  • H2bc13
  • H2bc15
  • H2bc7
  • Hist1h2bf
  • Hist1h2bj
  • Hist1h2bl
  • Hist1h2bn
 view
P10854 Histone H2B type 1-M
  • H2bc14
  • Hist1h2bm
 view
P62806 Histone H4
  • H4-12
  • H4-53
  • H4c1
  • H4c11
  • H4c12
  • H4c14
  • H4c16
  • H4c2
  • H4c3
  • H4c4
  • H4c6
  • H4c8
  • H4c9
  • H4f16
  • Hist1h4a
  • Hist1h4b
  • Hist1h4c
  • Hist1h4d
  • Hist1h4f
  • Hist1h4h
  • Hist1h4i
  • Hist1h4j
  • Hist1h4k
  • Hist1h4m
  • Hist2h4
  • Hist2h4a
  • Hist4h4
 view
P70399 TP53-binding protein 1
  • Tp53bp1
  • Trp53bp1
 view
Q0VGB7 Serine/threonine-protein phosphatase 4 regulatory subunit 2
  • Ppp4r2
 view
Q3UI43 BRISC and BRCA1-A complex member 1
  • Babam1
  • Merit40
  • Nba1
 view
Q4U2R1 E3 ubiquitin-protein ligase HERC2
  • Herc2
  • Jdf2
  • Kiaa0393
  • Rjs
 view
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025