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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Poly [ADP-ribose] polymerase tankyrase-1
Summary
- UniProt ID
- O95271
- Gene Symbol
-
- TNKS
- PARP5A
- PARPL
- TIN1
- TINF1
- TNKS1
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- O95271
- PubChem
- O95271
- The Human Metabolome Database
- HMDBP00912
- The O-GlcNAc Database
- O95271
Annotation
- Keyword
-
- 3D-structure
- ADP-ribosylation
- ANK repeat
- Alternative splicing
- Cytoskeleton
- Glycosyltransferase
- Golgi apparatus
- Membrane
- Metal-binding
- Mitosis
- NAD
- Nuclear pore complex
- Nucleotidyltransferase
- Phosphoprotein
- Reference proteome
- Repeat
- Telomere
- Ubl conjugation
- Wnt signaling pathway
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| chromosome, telomeric region |
| cytosol |
| pericentriolar material |
| nucleoplasm |
| nuclear pore |
| nuclear body |
| mitotic spindle pole |
| Golgi membrane |
| nucleus |
| cytoplasm |
| GO Term |
|---|
| NAD+ ADP-ribosyltransferase activity |
| nucleotidyltransferase activity |
| zinc ion binding |
| histone binding |
| NAD+-protein ADP-ribosyltransferase activity |
Sequence
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGTERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQKT
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Degradation of AXIN | Homo sapiens |
| Regulation of PTEN stability and activity | Homo sapiens |
| TCF dependent signaling in response to WNT | Homo sapiens |
| Ub-specific processing proteases | Homo sapiens |
| XAV939 stabilizes AXIN | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050424 | familial adenomatous polyposis | |
| DOID:0050569 | Seckel syndrome | |
| DOID:0050789 | tarsal-carpal coalition syndrome | |
| DOID:0050902 | medulloblastoma | |
| DOID:0060254 | Robinow syndrome | |
| DOID:0060578 | Noonan syndrome 1 | |
| DOID:0060580 | Noonan syndrome 2 | |
| DOID:0060581 | Noonan syndrome 3 | |
| DOID:0060582 | Noonan syndrome 4 | |
| DOID:0060583 | Noonan syndrome 5 |
