Submissions
GlyTouCan
Glycan Structure Repository
GlyComb
Glycoconjugate Repository
GlycoPOST
Glycomics MS raw data Repository
UniCarb-DR
Glycomics MS Repository for glycan annotations from GlycoWorkbench
All Resources
Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
Summary
- UniProt ID
- O95340
- Gene Symbol
-
- PAPSS2
- ATPSK2
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- O95340
- PubChem
- O95340
- The Human Metabolome Database
- HMDBP00353
- The O-GlcNAc Database
- O95340
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Disease variant
- Dwarfism
- Kinase
- Multifunctional enzyme
- Nucleotidyltransferase
- Reference proteome
- Gene Ontology (GO)
| GO Term |
|---|
| blood coagulation |
| phosphorylation |
| hormone metabolic process |
| bone development |
| 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process |
| sulfate assimilation |
| GO Term |
|---|
| cytosol |
| GO Term |
|---|
| adenylylsulfate kinase activity |
| sulfate adenylyltransferase (ATP) activity |
| nucleotidyltransferase activity |
| ATP binding |
Sequence
MSGIKKQKTENQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNRNLGFSPGDREENIRRIAEVAKLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSDYEKPETPERVLKTNLSTVSDCVHQVVELLQEQNIVPYTIIKDIHELFVPENKLDHVRAEAETLPSLSITKLDLQWVQVLSEGWATPLKGFMREKEYLQVMHFDTLLDDGVINMSIPIVLPVSAEDKTRLEGCSKFVLAHGGRRVAILRDAEFYEHRKEERCSRVWGTTCTKHPHIKMVMESGDWLVGGDLQVLEKIRWNDGLDQYRLTPLELKQKCKEMNADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDWRMKQHAAVLEEGVLDPKSTIVAIFPSPMLYAGPTEVQWHCRSRMIAGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKAKKAMDFYDPARHNEFDFISGTRMRKLAREGENPPDGFMAPKAWKVLTDYYRSLEKN
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Defective PAPSS2 causes SEMD-PA | Homo sapiens |
| Metabolism of ingested H2SeO4 and H2SeO3 into H2Se | Homo sapiens |
| Transport and synthesis of PAPS | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050690 | brachyolmia | |
| DOID:0050812 | spondyloepimetaphyseal dysplasia, Pakistani type | |
| DOID:0060249 | scoliosis | |
| DOID:1059 | intellectual disability | |
| DOID:11612 | polycystic ovary syndrome | |
| DOID:11613 | hyperandrogenism | |
| DOID:12347 | osteogenesis imperfecta | |
| DOID:12721 | multiple epiphyseal dysplasia | |
| DOID:12804 | mucopolysaccharidosis IV | |
| DOID:13359 | Ehlers-Danlos syndrome |
