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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
Summary
- UniProt ID
- O95340
- Gene Symbol
-
- PAPSS2
- ATPSK2
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- O95340
- PubChem
- O95340
- The Human Metabolome Database
- HMDBP00353
- The O-GlcNAc Database
- O95340
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Disease variant
- Dwarfism
- Kinase
- Multifunctional enzyme
- Nucleotidyltransferase
- Reference proteome
- Gene Ontology (GO)
| GO Term |
|---|
| blood coagulation |
| phosphorylation |
| hormone metabolic process |
| bone development |
| 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process |
| sulfate assimilation |
| GO Term |
|---|
| cytosol |
| GO Term |
|---|
| adenylylsulfate kinase activity |
| sulfate adenylyltransferase (ATP) activity |
| nucleotidyltransferase activity |
| ATP binding |
Sequence
MSGIKKQKTENQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNRNLGFSPGDREENIRRIAEVAKLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSDYEKPETPERVLKTNLSTVSDCVHQVVELLQEQNIVPYTIIKDIHELFVPENKLDHVRAEAETLPSLSITKLDLQWVQVLSEGWATPLKGFMREKEYLQVMHFDTLLDDGVINMSIPIVLPVSAEDKTRLEGCSKFVLAHGGRRVAILRDAEFYEHRKEERCSRVWGTTCTKHPHIKMVMESGDWLVGGDLQVLEKIRWNDGLDQYRLTPLELKQKCKEMNADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDWRMKQHAAVLEEGVLDPKSTIVAIFPSPMLYAGPTEVQWHCRSRMIAGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKAKKAMDFYDPARHNEFDFISGTRMRKLAREGENPPDGFMAPKAWKVLTDYYRSLEKN
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Defective PAPSS2 causes SEMD-PA | Homo sapiens |
| Metabolism of ingested H2SeO4 and H2SeO3 into H2Se | Homo sapiens |
| Transport and synthesis of PAPS | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:13515 | tuberous sclerosis | |
| DOID:14323 | Marfan syndrome | |
| DOID:14687 | diastrophic dysplasia | |
| DOID:2256 | osteochondrodysplasia | |
| DOID:3781 | anovulation | |
| DOID:381 | arthropathy | |
| DOID:420 | hypertrichosis | |
| DOID:4480 | achondroplasia | |
| DOID:6543 | acne | |
| DOID:758 | situs inversus |
