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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Coagulation factor XII
Summary
- UniProt ID
- P00748
- Gene Symbol
-
- F12
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011282
- GlyConnect
- GlyGen
- P00748
- PubChem
- P00748
- The Human Metabolome Database
- HMDBP02054
Annotation
- Keyword
-
- 3D-structure
- Direct protein sequencing
- Disease variant
- Disulfide bond
- EGF-like domain
- Fibrinolysis
- Glycoprotein
- Kringle
- Reference proteome
- Repeat
- Secreted
- Serine protease
- Signal
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| fibrinolysis |
| innate immune response |
| positive regulation of fibrinolysis |
| GO Term |
|---|
| rough endoplasmic reticulum |
| extracellular region |
| extracellular space |
| plasma membrane |
| collagen-containing extracellular matrix |
| extracellular exosome |
| GO Term |
|---|
| serine-type endopeptidase activity |
| calcium ion binding |
| misfolded protein binding |
Sequence
MRALLLLGFLLVSLESTLSIPPWEAPKEHKYKAEEHTVVLTVTGEPCHFPFQYHRQLYHKCTHKGRPGPQPWCATTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNMPSGPHCLCPQHLTGNHCQKEKCFEPQLLRFFHKNEIWYRTEQAAVARCQCKGPDAHCQRLASQACRTNPCLHGGRCLEVEGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQPWASEATYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQAAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWIREHTVS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 43 |
|
|||
| 109 | O-linked (Fuc) threonine |
|
||
| 181 |
|
|||
| 249 | N-linked (GlcNAc...) asparagine | |||
| 285 |
|
|||
| 299 | O-linked (GalNAc...) threonine | |||
| 305 | O-linked (GalNAc...) threonine |
|
||
| 308 | O-linked (GalNAc...) serine |
|
||
| 311 |
|
|||
| 328 | O-linked (GalNAc...) threonine |
G43417UB
G22310AV
G75983OB
G84452RH
G14994KB
G45395BF
G08918WF
G00912UN
G59626AS
G10486CT
G95865ZB
G57321FI
G53434XO
G58001LT
G29068FM
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Defective SERPING1 causes hereditary angioedema | Homo sapiens |
| Defective factor XII causes hereditary angioedema | Homo sapiens |
| Intrinsic Pathway of Fibrin Clot Formation | Homo sapiens |
