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Guidelines
MIRAGE
Coagulation factor XII

Summary
UniProt ID
P00748
Gene Symbol
  • F12
Gene ID
2161
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011282
GlyConnect
GlyGen
P00748
PubChem
P00748
The Human Metabolome Database
HMDBP02054
Re-Glyco
P00748
Annotation
Keyword
  • 3D-structure
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • EGF-like domain
  • Fibrinolysis
  • Glycoprotein
  • Kringle
  • Reference proteome
  • Repeat
  • Secreted
  • Serine protease
  • Signal
  • Zymogen
Gene Ontology (GO)
Displaying all 6 entries
GO Term
extracellular region
extracellular space
plasma membrane
collagen-containing extracellular matrix
rough endoplasmic reticulum
extracellular exosome
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MRALLLLGFLLVSLESTLSIPPWEAPKEHKYKAEEHTVVLTVTGEPCHFPFQYHRQLYHKCTHKGRPGPQPWCATTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNMPSGPHCLCPQHLTGNHCQKEKCFEPQLLRFFHKNEIWYRTEQAAVARCQCKGPDAHCQRLASQACRTNPCLHGGRCLEVEGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQPWASEATYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQAAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWIREHTVS
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying entries 1 - 10 of 15 in total
Position Description PubMed ID GlyTouCan ID Source
43
109 O-linked (Fuc) threonine
181
249 N-linked (GlcNAc...) asparagine
285
299 O-linked (GalNAc...) threonine
305 O-linked (GalNAc...) threonine
308 O-linked (GalNAc...) serine
311
328 O-linked (GalNAc...) threonine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 3 entries
Pathway Name Organism
Defective SERPING1 causes hereditary angioedema Homo sapiens
Defective factor XII causes hereditary angioedema Homo sapiens
Intrinsic Pathway of Fibrin Clot Formation Homo sapiens
Disease
Displaying all 7 entries
DO ID Disease Name Source
DOID:0080940 hereditary angioedema type III
DOID:14735 hereditary angioedema
DOID:1558 angioedema
DOID:2231 factor XII deficiency
DOID:224 transient cerebral ischemia
DOID:3525 middle cerebral artery infarction
DOID:5844 myocardial infarction
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025