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Tissue-type plasminogen activator

Summary

UniProt ID

P00750

Gene Symbol

PLAT

Organism

Homo sapiens (human)

External Links

GlyConnect

GlyGen

P00750

PubChem

P00750

The Human Metabolome Database

HMDBP01868

Annotation

Keyword

3D-structure
Alternative splicing
Cleavage on pair of basic residues
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Kringle
Pharmaceutical
Plasminogen activation
Reference proteome
Repeat
Secreted
Serine protease
Signal
Zymogen

Gene Ontology (GO)

Displaying entries **1 - 10** of 13 in total

1

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GO Term
response to hypoxia
proteolysis
blood coagulation
protein modification process
fibrinolysis
negative regulation of proteolysis
negative regulation of fibrinolysis
plasminogen activation
trans-synaptic signaling by BDNF, modulating synaptic transmission
negative regulation of plasminogen activation

Displaying **all 10** entries
GO Term
cell surface
apical part of cell
extracellular region
extracellular space
cytoplasm
secretory granule
serine protease inhibitor complex
extracellular exosome
Schaffer collateral - CA1 synapse
glutamatergic synapse

Displaying **all 3** entries
GO Term
serine-type endopeptidase activity
signaling receptor binding
phosphoprotein binding

Site Annotations

Displaying 1 entry
Position	Description
253	Not glycosylated

Annotation information from UniProt.

Sequence

MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPVLRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 8** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
96	O-linked (Fuc) threonine	1900431		UniProt GlyGen
152	N-linked (GlcNAc...) asparagine	2513186	G95861KV G77038WW G94141FZ G97832IV G01769FS G21415RL G41304KE G44533KV G68758PE G48848IF G83461WR G92570PJ G35808UX G85542KD G88417ED G24440EI G09482NW G40702WU G96063MG G88461FF G13151XE G68668TB G83161QT G44842OK G12398HZ G39188ZX G80966KZ G06110VR G55220VL G77964WB	UniProt GlyGen GlyConnect
177				GlyGen
219	N-linked (GlcNAc...) asparagine; partial	2513186	G98259QP G39172SO G05813WO G88027AL G69834CE G94531EZ G95861KV G94974XB G26076FX G15169WU G45209NR G91413ZX G93860XO G77038WW G94141FZ G11629QQ G62765SF G91905FJ G26915XM G97832IV G01769FS G97428EW G21415RL G24511TX G81198YO G06330RB G37022BP G70511VE G17689DH G22310AV G41304KE G44533KV G68758PE G08110WX G48848IF G58481XO G72667IM G46691LC G04657PL G27058EU G83461WR G00463XD G02000AU G82779CI G43814TV G92570PJ G35808UX G50757KG G85542KD G06772YH G88417ED G92617LF G24440EI G09482NW G40702WU G29972ZX G96063MG G47108UC G88461FF G13151XE G68668TB G83161QT G44842OK G12398HZ G80966KZ G55220VL G13456GP	UniProt GlyGen GlyConnect
483	N-linked (GlcNAc...) asparagine	2513186	G95861KV G53854XZ G77038WW G94141FZ G26915XM G97832IV G01769FS G21415RL G81198YO G41304KE G45395BF G44533KV G68758PE G08110WX G48848IF G58481XO G72667IM G27058EU G83461WR G00463XD G02000AU G82779CI G43814TV G92570PJ G35808UX G50757KG G85542KD G06772YH G42124LM G88417ED G92617LF G24440EI G09482NW G40702WU G29972ZX G96063MG G47108UC G88461FF G13151XE G68668TB G83161QT G44842OK G12398HZ G80966KZ G55220VL G77964WB G74724QE	UniProt GlyGen GlyConnect
485			G57321FI	GlyGen
487			G57321FI	GlyGen
			G69834CE G95861KV G01629KW G85618VM G46665ZP G85194VU G98481KT G15169WU G45209NR G27696FL G26034OB G92081HT G17276XO G77038WW G94141FZ G11629QQ G45661NA G74239ZQ G13728QT G83386PJ G01769FS G41917DR G00155YT G44121LY G81263BG G06330RB G37022BP G70511VE G17689DH G22310AV G41304KE G44533KV G96416FQ G68758PE G93683YO G44444MB G53752TA G83461WR G84452RH G23294PN G92570PJ G03382KH G88417ED G23863VK G78059CC G24440EI G82463GQ G09482NW G14260UH G40702WU G64527OM G23432EQ G96063MG G10256JP G45981GB G88461FF G13151XE G50045TK G05724UK G68668TB G83161QT G39188ZX G80966KZ G06110VR G55220VL G96881BQ	GlyGen GlyConnect