GlyCosmos Portal

Submissions

Protransforming growth factor alpha

Summary

UniProt ID

P01135

Gene Symbol

TGFA

Gene ID

7039

Organism

Homo sapiens (human)

External Links

PubChem: P01135
The Human Metabolome Database: HMDBP12416
Re-Glyco: P01135

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
EGF-like domain
Glycoprotein
Growth factor
Mitogen
Palmitate
Reference proteome
Secreted
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 10** of 11 in total

1

2

Next ›

Last »
GO Term
extracellular region
extracellular space
plasma membrane
cytoplasmic vesicle
endoplasmic reticulum membrane
cell surface
basolateral plasma membrane
perinuclear region of cytoplasm
ER to Golgi transport vesicle membrane
endoplasmic reticulum-Golgi intermediate compartment membrane

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 13 in total

1

2

Next ›

Last »
GO Term
positive regulation of cell division
angiogenesis
positive regulation of MAPK cascade
mammary gland alveolus development
hepatocyte proliferation
epidermal growth factor receptor signaling pathway
positive regulation of peptidyl-tyrosine phosphorylation
cell surface receptor signaling pathway
positive regulation of cell population proliferation
intracellular signal transduction

Displaying **all 4** entries
GO Term
growth factor activity
epidermal growth factor receptor binding
receptor ligand activity
transmembrane receptor protein tyrosine kinase activator activity

Annotation information from UniProt.

Sequence

MVPSAGQLALFALGIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
25	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 19 in total

1

2

Next ›

Last »
Pathway Name	Organism
COPII-mediated vesicle transport	Homo sapiens
Cargo concentration in the ER	Homo sapiens
Cargo recognition for clathrin-mediated endocytosis	Homo sapiens
Clathrin-mediated endocytosis	Homo sapiens
Constitutive Signaling by Aberrant PI3K in Cancer	Homo sapiens
EGFR downregulation	Homo sapiens
EGFR interacts with phospholipase C-gamma	Homo sapiens
Estrogen-dependent gene expression	Homo sapiens
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Homo sapiens
Extra-nuclear estrogen signaling	Homo sapiens