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Pro-opiomelanocortin

Summary

UniProt ID

P01194

Gene Symbol

Pomc
Pomc2

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P01194
Re-Glyco: P01194

Annotation

Keyword

Acetylation
Amidation
Cleavage on pair of basic residues
Direct protein sequencing
Endorphin
Glycoprotein
Hormone
Phosphoprotein
Reference proteome
Secreted
Signal

Gene Ontology (GO)

Displaying **all 5** entries
GO Term
extracellular region
extracellular space
cytoplasm
secretory granule
peroxisomal matrix

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 19 in total

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GO Term
negative regulation of tumor necrosis factor production
response to ethanol
neuropeptide signaling pathway
calcium-mediated signaling
response to alcohol
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
generation of precursor metabolites and energy
signal transduction
cell-cell signaling
feeding behavior

Displaying **all 6** entries
GO Term
G protein-coupled receptor binding
type 3 melanocortin receptor binding
type 4 melanocortin receptor binding
type 1 melanocortin receptor binding
signaling receptor binding
hormone activity

Annotation information from UniProt.

Sequence

MPRFCNSRSGALLLALLLQTSIDVWSWCLESSQCQDLTTESNLLACIRACRLDLSAETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGPRNSSSAGGSAQRRAEEETAGGDGRPEPSPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNVAENESAEAFPLEFKRELEGEQPDGLEQVLEPDTEKADGPYRVEHFRWGNPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNVHKKGQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
152	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 8** entries
Pathway Name	Organism
Androgen biosynthesis	Rattus norvegicus
Endogenous sterols	Rattus norvegicus
G alpha (i) signalling events	Rattus norvegicus
G-protein activation	Rattus norvegicus
Glucocorticoid biosynthesis	Rattus norvegicus
Opioid Signalling	Rattus norvegicus
Peptide hormone biosynthesis	Rattus norvegicus
Peptide ligand-binding receptors	Rattus norvegicus

Disease

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050741	alcohol dependence	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources
DOID:9976	heroin dependence	Alliance of Genome Resources