Apolipoprotein A-I

Summary
UniProt ID
P02647
Gene Symbol
  • APOA1
Gene ID
335
Organism
Homo sapiens (human)
GlyGen
P02647
PubChem
P02647
The Human Metabolome Database
HMDBP01620
RaftProt
P02647
Re-Glyco
P02647
Annotation
Keyword
  • 3D-structure
  • Amyloid
  • Amyloidosis
  • Atherosclerosis
  • Cholesterol metabolism
  • Direct protein sequencing
  • Disease variant
  • Glycation
  • HDL
  • Lipid transport
  • Neuropathy
  • Oxidation
  • Palmitate
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • Secreted
  • Signal
Gene Ontology (GO)
Sequence
MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ
Glycosylation Sites
Displaying all 4 entries
Position Description PubMed ID GlyTouCan ID Source
220
221
228
263 N-linked (Glc) (glycation) lysine
Feature
204060801001201401601802002202402601267
20406080100120140160180200220240260MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ
Domains & sites
PTM
20406080100120140160180200220240260MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 1 - 10 of 17 in total
Pathway Name Organism
ABC transporters in lipid homeostasis Homo sapiens
Amyloid fiber formation Homo sapiens
Chylomicron assembly Homo sapiens
Chylomicron remodeling Homo sapiens
Defective ABCA1 causes TGD Homo sapiens
HDL assembly Homo sapiens
HDL clearance Homo sapiens
HDL remodeling Homo sapiens
Heme signaling Homo sapiens
PPARA activates gene expression Homo sapiens
Disease
Displaying all 8 entries
DO ID Disease Name Source
DOID:0080547 metabolic dysfunction-associated steatohepatitis
DOID:0080958 primary hypoalphalipoproteinemia 2
DOID:10652 Alzheimer's disease
DOID:13810 familial hypercholesterolemia
DOID:1387 hypolipoproteinemia
DOID:1936 atherosclerosis
DOID:5844 myocardial infarction
DOID:9074 systemic lupus erythematosus

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025