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MIRAGE
Coagulation factor XI

Summary
UniProt ID
P03951
Gene Symbol
  • F11
Gene ID
2160
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011341
GlyConnect
GlyGen
P03951
PubChem
P03951
Re-Glyco
P03951
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Blood coagulation
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Heparin-binding
  • Reference proteome
  • Repeat
  • Secreted
  • Serine protease
  • Signal
Gene Ontology (GO)
Displaying all 5 entries
GO Term
extracellular region
extracellular space
plasma membrane
membrane
extracellular exosome
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQAV
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 5 entries
Position Description PubMed ID GlyTouCan ID Source
90 N-linked (GlcNAc...) (complex) asparagine
126 N-linked (GlcNAc...) (complex) asparagine
163 N-linked (GlcNAc...) (complex) asparagine; atypical
450 N-linked (GlcNAc...) (complex) asparagine
491 N-linked (GlcNAc...) (complex) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 2 entries
Pathway Name Organism
Defective F9 activation Homo sapiens
Intrinsic Pathway of Fibrin Clot Formation Homo sapiens
Disease
Displaying all 2 entries
DO ID Disease Name Source
DOID:0060903 thrombosis
DOID:2229 factor XI deficiency
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025