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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Phosphatidylcholine-sterol acyltransferase
Summary
- UniProt ID
- P04180
- Gene Symbol
-
- LCAT
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011357
- GlyConnect
- GlyGen
- P04180
- PubChem
- P04180
- SwissLipids
- The Human Metabolome Database
- HMDBP00069
Annotation
- Keyword
-
- 3D-structure
- Acyltransferase
- Cholesterol metabolism
- Corneal dystrophy
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Hydrolase
- Reference proteome
- Secreted
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| high-density lipoprotein particle remodeling |
| regulation of high-density lipoprotein particle assembly |
| GO Term |
|---|
| extracellular region |
| extracellular space |
| extracellular exosome |
| high-density lipoprotein particle |
Sequence
MGPPGSPWQWVTLLLGLLLPPAAPFWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNQLEAKLDKPDVVNWMCYRKTEDFFTIWLDLNMFLPLGVDCWIDNTRVVYNRSSGLVSNAPGVQIRVPGFGKTYSVEYLDSSKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLEPGQQEEYYRKLAGLVEEMHAAYGKPVFLIGHSLGCLHLLYFLLRQPQAWKDRFIDGFISLGAPWGGSIKPMLVLASGDNQGIPIMSSIKLKEEQRITTTSPWMFPSRMAWPEDHVFISTPSFNYTGRDFQRFFADLHFEEGWYMWLQSRDLLAGLPAPGVEVYCLYGVGLPTPRTYIYDHGFPYTDPVGVLYEDGDDTVATRSTELCGLWQGRQPQPVHLLPLHGIQHLNMVFSNLTLEHINAILLGAYRQGPPASPTASPEPPPPE
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 44 | N-linked (GlcNAc...) (complex) asparagine | |||
| 108 | N-linked (GlcNAc...) (complex) asparagine |
|
||
| 296 | N-linked (GlcNAc...) (complex) asparagine | |||
| 408 | N-linked (GlcNAc...) (complex) asparagine |
|
||
| 424 |
|
|||
| 431 | O-linked (GalNAc...) threonine |
|
||
| 433 | O-linked (GalNAc...) serine |
|
||
|
|
G33791AF
G06247RL
G04854VP
G63041LO
G12341GU
G70232NH
G27947YN
G81263BG
G22310AV
G00273SJ
G08918WF
G00912UN
G48414YA
G66760KM
G06356OH
G57321FI
G63889NK
G90093AU
G72797UR
G74286KY
G86357DX
G20425TQ
G22388FD
G29857RC
G23863VK
G78059CC
G36191CD
G50045TK
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| HDL remodeling | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:1287 | cardiovascular system disease | |
| DOID:13068 | renal osteodystrophy | |
| DOID:13739 | nutmeg liver | |
| DOID:13809 | familial combined hyperlipidemia | |
| DOID:13810 | familial hypercholesterolemia | |
| DOID:1386 | abetalipoproteinemia | |
| DOID:1387 | hypolipoproteinemia | |
| DOID:1388 | Tangier disease | |
| DOID:1391 | Norum disease | |
| DOID:14118 | familial lipoprotein lipase deficiency |
