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MIRAGE
Histidine-rich glycoprotein

Summary
UniProt ID
P04196
Gene Symbol
  • HRG
Gene ID
3273
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011358
GlyConnect
GlyGen
P04196
PubChem
P04196
The Human Metabolome Database
HMDBP02730
Re-Glyco
P04196
Annotation
Keyword
  • Angiogenesis
  • Chemotaxis
  • Cleavage on pair of basic residues
  • Copper
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Fibrinolysis
  • Glycoprotein
  • Heparin-binding
  • Metal-binding
  • Reference proteome
  • Repeat
  • Secreted
  • Signal
  • Thrombophilia
  • Zinc
Gene Ontology (GO)
Displaying all 7 entries
GO Term
platelet alpha granule lumen
collagen-containing extracellular matrix
cell surface
extracellular exosome
blood microparticle
extracellular region
plasma membrane
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MKALIAALLLITLQYSCAVSPTDCSAVEPEAEKALDLINKRRRDGYLFQLLRIADAHLDRVENTTVYYLVLDVQESDCSVLSRKYWNDCEPPDSRRPSEIVIGQCKVIATRHSHESQDLRVIDFNCTTSSVSSALANTKDSPVLIDFFEDTERYRKQANKALEKYKEENDDFASFRVDRIERVARVRGGEGTGYFVDFSVRNCPRHHFPRHPNVFGFCRADLFYDVEALDLESPKNLVINCEVFDPQEHENINGVPPHLGHPFHWGGHERSSTTKPPFKPHGSRDHHHPHKPHEHGPPPPPDERDHSHGPPLPQGPPPLLPMSCSSCQHATFGTNGAQRHSHNNNSSDLHPHKHHSHEQHPHGHHPHAHHPHEHDTHRQHPHGHHPHGHHPHGHHPHGHHPHGHHPHCHDFQDYGPCDPPPHNQGHCCHGHGPPPGHLRRRGPGKGPRPFHCRQIGSVYRLPPLRKGEVLPLPEANFPSFPLPHHKHPLKPDNQPFPQSVSESCPGKFKSGFPQVSMFFTHTFPK
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 7 entries
Position Description PubMed ID GlyTouCan ID Source
63 N-linked (GlcNAc...) asparagine
125 N-linked (GlcNAc...) asparagine
271
273
274
344 N-linked (GlcNAc...) asparagine
345 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 2 entries
Pathway Name Organism
Dissolution of Fibrin Clot Homo sapiens
Platelet degranulation Homo sapiens
Disease
Displaying all 2 entries
DO ID Disease Name Source
DOID:0060903 thrombosis
DOID:0111903 thrombophilia due to HRG deficiency
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025