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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Amyloid-beta precursor protein
Summary
- UniProt ID
- P05067
- Gene Symbol
-
- APP
- A4
- AD1
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011374
- GlyConnect
- GlyGen
- P05067
- PubChem
- P05067
- The Human Metabolome Database
- HMDBP01991
- RaftProt
- P05067
- O-GlcNAcAtlas
- P05067
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Alzheimer disease
- Amyloid
- Amyloidosis
- Apoptosis
- Cell adhesion
- Cell membrane
- Cell projection
- Coated pit
- Copper
- Cytoplasm
- Cytoplasmic vesicle
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Endocytosis
- Endoplasmic reticulum
- Endosome
- Golgi apparatus
- Heparin-binding
- Iron
- Isopeptide bond
- Metal-binding
- Neurodegeneration
- Notch signaling pathway
- Nucleus
- Oxidation
- Phosphoprotein
- Proteoglycan
- Reference proteome
- Secreted
- Serine protease inhibitor
- Signal
- Sulfation
- Transmembrane helix
- Ubl conjugation
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| recycling endosome |
| nuclear envelope lumen |
| platelet alpha granule lumen |
| clathrin-coated pit |
| synaptic vesicle |
| endosome lumen |
| presynaptic active zone |
| extracellular exosome |
| smooth endoplasmic reticulum |
| trans-Golgi network membrane |
Sequence
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 22 |
|
|||
| 107 |
|
|||
| 276 |
|
|||
| 279 |
|
|||
| 280 |
|
|||
| 352 |
|
|||
| 353 |
|
|||
| 360 |
|
|||
| 364 |
|
|||
| 366 |
|
G43417UB
G57321FI
G53434XO
G58001LT
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Advanced glycosylation endproduct receptor signaling | Homo sapiens |
| Amyloid fiber formation | Homo sapiens |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | Homo sapiens |
| Formyl peptide receptors bind formyl peptides and many other ligands | Homo sapiens |
| G alpha (i) signalling events | Homo sapiens |
| G alpha (q) signalling events | Homo sapiens |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | Homo sapiens |
| Lysosome Vesicle Biogenesis | Homo sapiens |
| Platelet degranulation | Homo sapiens |
| Post-translational protein phosphorylation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
