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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Alkaline phosphatase, tissue-nonspecific isozyme
Summary
- UniProt ID
- P05186
- Gene Symbol
-
- ALPL
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Biomineralization
- Calcium
- Cell membrane
- Direct protein sequencing
- Disease variant
- Disulfide bond
- GPI-anchor
- Hydrolase
- Magnesium
- Metal-binding
- Mitochondrion
- Phosphoprotein
- Reference proteome
- Signal
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| plasma membrane |
| membrane |
| extracellular matrix |
| extracellular exosome |
| mitochondrial membrane |
| mitochondrial intermembrane space |
| side of membrane |
Sequence
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 48 |
|
|||
| 140 | N-linked (GlcNAc...) asparagine | |||
| 230 | N-linked (GlcNAc...) asparagine | |||
| 232 |
|
|||
| 271 | N-linked (GlcNAc...) asparagine | |||
| 302 |
|
|
||
| 303 | N-linked (GlcNAc...) asparagine |
|
||
| 430 | N-linked (GlcNAc...) asparagine | |||
| 439 |
|
|
||
| 440 |
|
|
G49108TO
G48414YA
G80920RR
G62765YT
G02815KT
G05962QB
G13131HA
G80479JV
G85282JO
G70441OD
G83646BJ
G80075MS
G68490OW
G86880BF
G27947YN
G79666IR
G92135MA
G98611JV
G07246CJ
G10819WX
G40926MX
G43223CG
G08918WF
G49906RN
G87661QW
G27058EU
G41071NU
G59626AS
G65184UU
G90659AW
G10486CT
G55412XP
G15169WU
G11629QQ
G12959FT
G81263BG
G22310AV
G84452RH
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Post-translational modification: synthesis of GPI-anchored proteins | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050463 | campomelic dysplasia | |
| DOID:0050763 | ARC syndrome | |
| DOID:0060180 | colitis | |
| DOID:0060189 | ileitis | |
| DOID:0060190 | ileocolitis | |
| DOID:0070086 | schizophrenia 10 | |
| DOID:0080001 | bone disease | |
| DOID:0110334 | osteogenesis imperfecta type 1 | |
| DOID:0110335 | osteogenesis imperfecta with opalescent teeth, blue sclerae and wormian bones but without fractures | |
| DOID:0110336 | osteogenesis imperfecta type 8 |
