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alkaline phosphatase, biomineralization associated

Summary

Gene Symbol

ALPL

Aliases

TNALP
TNAP
TNSALP
tissue non-specific alkaline phosphatase

Organism

Homo sapiens (human)

External Links

NCBI Gene

249

HGNC

438

KEGG Gene ID

hsa:249

PubChem

249

Alliance of Genome Resources

HGNC:438

Annotation

Keyword

3D-structure
Alternative splicing
Biomineralization
Calcium
Cell membrane
Direct protein sequencing
Disease variant
Disulfide bond
GPI-anchor
Hydrolase
Magnesium
Metal-binding
Mitochondrion
Phosphoprotein
Reference proteome
Signal
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
P05186	Alkaline phosphatase liver/bone/kidney isozyme Phosphoamidase Phosphocreatine phosphatase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
skeletal system development	TAS	9781036
osteoblast differentiation	HDA	16210410
endochondral ossification	IEA
developmental process involved in reproduction	IEA
cellular homeostasis	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

organonitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

pyridoxal phosphate metabolic process

cellular aromatic compound metabolic process [inference]

pyridoxal phosphate metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

pyridoxal phosphate metabolic process

organophosphate metabolic process [inference]

pyridoxal phosphate metabolic process

cellular nitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

heterocycle metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

small molecule metabolic process [inference]

vitamin metabolic process [inference]

water-soluble vitamin metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

organic substance metabolic process [inference]

cellular aldehyde metabolic process [inference]

pyridoxal phosphate metabolic process

organophosphate metabolic process [inference]

pyridoxal phosphate metabolic process

organic cyclic compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

organonitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

organic hydroxy compound metabolic process [inference]

pyridoxal phosphate metabolic process

futile creatine cycle

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

pyridoxal phosphate metabolic process

cellular aromatic compound metabolic process [inference]

pyridoxal phosphate metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

pyridoxal phosphate metabolic process

organophosphate metabolic process [inference]

pyridoxal phosphate metabolic process

cellular nitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

heterocycle metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound

reproductive process [inference]

developmental process involved in reproduction

multicellular organismal process [inference]

ossification [inference]

replacement ossification [inference]

endochondral ossification

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

inhibition of non-skeletal tissue mineralization

developmental process [inference]

developmental process involved in reproduction

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development

bone mineralization

tooth mineralization [inference]

cementum mineralization

system development [inference]

skeletal system development

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

homeostatic process [inference]

cellular homeostasis

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

inhibition of non-skeletal tissue mineralization

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

inorganic ion homeostasis [inference]

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to organonitrogen compound [inference]

response to vitamin B6

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

cellular response to organic cyclic compound

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to cytokine [inference]

response to macrophage colony-stimulating factor

cellular response to organic substance [inference]

cellular response to organic cyclic compound

response to inorganic substance [inference]

response to sodium phosphate

response to antibiotic

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to vitamin B6

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to salt [inference]

response to sodium phosphate

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

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GO Term	Evidence Code	PMID
extracellular region	TAS
mitochondrial intermembrane space	ISS
plasma membrane	TAS
plasma membrane	IDA	2220817 33821301
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane

plasma membrane

organelle membrane [inference]

mitochondrial membrane

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

mitochondrial intermembrane space

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane

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GO Term	Evidence Code	PMID
alkaline phosphatase activity	IDA	12162492 33821301
alkaline phosphatase activity	IBA
inorganic diphosphate phosphatase activity	IEA
calcium ion binding	IDA	11395499
pyrophosphatase activity	IDA	12162492 19874193

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity

inorganic diphosphate phosphatase activity

nucleoside diphosphate phosphatase activity [inference]

ADP phosphatase activity

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

hydrolase activity, acting on acid phosphorus-nitrogen bonds [inference]

phosphoamidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alkaline phosphatase

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
alkaline phosphatase activity
metal ion binding

Displaying **all 2** entries
InterPro
Alkaline phosphatase
Alkaline-phosphatase-like, core domain superfamily

Human Protein Atlas

ENSG00000162551

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K01077

Name

alkaline phosphatase [EC:3.1.3.1]

References

10628988

Rhea

RHEA:12977

H₂O + N-phosphocreatine

phosphate + creatine

Enzyme

3.9.1.1

PMID

RHEA:15017

H₂O + a phosphate monoester

an alcohol + phosphate

Enzyme

PMID

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0110913	adult hypophosphatasia	Alliance of Genome Resources
DOID:0110914	infantile hypophosphatasia	Alliance of Genome Resources
DOID:0110915	childhood hypophosphatasia	Alliance of Genome Resources
DOID:14213	hypophosphatasia	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000121	Nephrocalcinosis
HP:0000164	Abnormality of the dentition
HP:0000268	Dolichocephaly
HP:0000520	Proptosis
HP:0000592	Blue sclerae
HP:0000670	Carious teeth
HP:0000737	Irritability
HP:0000773	Short ribs

Displaying **all 3** entries
Disease ID	Disease Name
OMIM:241510	obsolete childhood hypophosphatasia
OMIM:241500	obsolete infantile hypophosphatasia
OMIM:146300	obsolete adult hypophosphatasia

PubChem Disease

GHR Health Conditions

Hypophosphatasia

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Hypophosphatasia

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	248	SGD:S000002889
Xenopus tropicalis	249	Xenbase:XB-GENE-1010301
Saccharomyces cerevisiae S288C	250	SGD:S000002889
Saccharomyces cerevisiae S288C	251	SGD:S000002889
Mus musculus	11647	Xenbase:XB-GENE-1010301	MOUSE41351
Saccharomyces cerevisiae S288C	11650	SGD:S000002889
Rattus norvegicus	25586	Xenbase:XB-GENE-1010301	RATNO32949
Xenopus tropicalis	43671	Xenbase:XB-GENE-1010301
Saccharomyces cerevisiae S288C	76768	SGD:S000002889
Bos taurus	280994		BOVIN25254

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements