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alkaline phosphatase, biomineralization associated

Summary

Gene Symbol

ALPL

Aliases

TNALP
TNAP
TNSALP
tissue non-specific alkaline phosphatase

Organism

Homo sapiens (human)

External Links

NCBI Gene

249

HGNC

438

KEGG Gene ID

hsa:249

PubChem

249

Alliance of Genome Resources

HGNC:438

Annotation

Keyword

3D-structure
Alternative splicing
Biomineralization
Calcium
Cell membrane
Direct protein sequencing
Disease variant
Disulfide bond
GPI-anchor
Hydrolase
Magnesium
Metal-binding
Mitochondrion
Phosphoprotein
Reference proteome
Signal
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
P05186	Alkaline phosphatase liver/bone/kidney isozyme Phosphoamidase Phosphocreatine phosphatase

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
endochondral ossification	IEA
response to lipopolysaccharide	IEA
cellular response to organic cyclic compound	IEA
developmental process involved in reproduction	IEA
skeletal system development		9781036

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

organonitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

pyridoxal phosphate metabolic process

cellular aromatic compound metabolic process [inference]

pyridoxal phosphate metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

organophosphate metabolic process [inference]

pyridoxal phosphate metabolic process

cellular nitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

heterocycle metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

small molecule metabolic process [inference]

vitamin metabolic process [inference]

water-soluble vitamin metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

organic substance metabolic process [inference]

cellular aldehyde metabolic process [inference]

pyridoxal phosphate metabolic process

organophosphate metabolic process [inference]

pyridoxal phosphate metabolic process

organic cyclic compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

organonitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

organic hydroxy compound metabolic process [inference]

pyridoxal phosphate metabolic process

futile creatine cycle

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

pyridoxal phosphate metabolic process

cellular aromatic compound metabolic process [inference]

pyridoxal phosphate metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

organophosphate metabolic process [inference]

pyridoxal phosphate metabolic process

cellular nitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

heterocycle metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound

reproductive process [inference]

developmental process involved in reproduction

multicellular organismal process [inference]

ossification [inference]

replacement ossification [inference]

endochondral ossification

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

inhibition of non-skeletal tissue mineralization

developmental process [inference]

developmental process involved in reproduction

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

tooth mineralization [inference]

cementum mineralization

system development [inference]

skeletal system development

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

homeostatic process [inference]

cellular homeostasis

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

inhibition of non-skeletal tissue mineralization

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

inorganic ion homeostasis [inference]

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to organonitrogen compound [inference]

response to vitamin B6

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

cellular response to organic cyclic compound

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to cytokine [inference]

response to macrophage colony-stimulating factor

cellular response to organic substance [inference]

cellular response to organic cyclic compound

response to inorganic substance [inference]

response to sodium phosphate

response to antibiotic

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to vitamin B6

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to salt [inference]

response to sodium phosphate

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

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GO Term	Evidence Code	PMID
extracellular matrix	IEA
extracellular region
mitochondrial membrane	ISS
plasma membrane	IBA IDA TAS	2220817 33821301
side of membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane

plasma membrane

organelle membrane [inference]

mitochondrial membrane

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

mitochondrial intermembrane space

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane

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GO Term	Evidence Code	PMID
ADP phosphatase activity	IEA
phosphoamidase activity	ISS
pyridoxal phosphatase activity	IDA	12162492 2220817
alkaline phosphatase activity	IBA IDA	12162492 33821301
phosphoethanolamine phosphatase activity	IDA	2220817

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity

inorganic diphosphate phosphatase activity

nucleoside diphosphate phosphatase activity [inference]

ADP phosphatase activity

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

hydrolase activity, acting on acid phosphorus-nitrogen bonds [inference]

phosphoamidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000162551

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K01077

Name

alkaline phosphatase [EC:3.1.3.1]

References

10628988

Rhea

RHEA:12977

H₂O + N-phosphocreatine

phosphate + creatine

Enzyme

3.9.1.1

PMID

RHEA:15017

H₂O + a phosphate monoester

an alcohol + phosphate

Enzyme

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0050463	campomelic dysplasia	DisGeNET
DOID:0050763	ARC syndrome	DisGeNET
DOID:0060180	colitis	DisGeNET
DOID:0060189	ileitis	DisGeNET
DOID:0060190	ileocolitis	DisGeNET
DOID:0070086	schizophrenia 10	DisGeNET
DOID:0080001	bone disease	DisGeNET
DOID:0110334	osteogenesis imperfecta type 1	DisGeNET
DOID:0110335	osteogenesis imperfecta with opalescent teeth, blue sclerae and wormian bones but without fractures	DisGeNET
DOID:0110336	osteogenesis imperfecta type 8	DisGeNET

The Human Phenotype Ontology

Displaying entries **11 - 20** of 57 in total

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HPO ID	HPO Term
HP:0000897	Rachitic rosary
HP:0000926	Platyspondyly
HP:0000934	Chondrocalcinosis
HP:0001024	Skin dimple over apex of long bone angulation
HP:0001250	Seizure
HP:0001252	Hypotonia
HP:0001363	Craniosynostosis
HP:0001508	Failure to thrive
HP:0001522	Death in infancy
HP:0001561	Polyhydramnios

Displaying **all 3** entries
Disease ID	Disease Name
OMIM:146300	obsolete adult hypophosphatasia
OMIM:241510	obsolete childhood hypophosphatasia
OMIM:241500	obsolete infantile hypophosphatasia

PubChem Disease

GHR Health Conditions

Hypophosphatasia

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Hypophosphatasia

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	35981	FB:FBgn0033423
Drosophila melanogaster	41135	FB:FBgn0043791
Drosophila melanogaster	42482	FB:FBgn0038845
Ciona intestinalis	445594		CIOIN16078
Callorhinchus milii	103181381		CALMI22615
Danio rerio	393982	ZFIN:ZDB-GENE-040420-1	DANRE03106
Ictalurus punctatus	108255202		ICTPU16782
Electrophorus electricus	113586394		ELEEL05419
Salmo trutta	115150725		SALTR32320
Salmo trutta	115207713		SALTR39539

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements