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Standards Ontologies Notations
Complement C2

Summary
UniProt ID
P06681
Gene Symbol
  • C2
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011405
GlyConnect
GlyGen
P06681
PubChem
P06681
Annotation
Keyword
  • 3D-structure
  • Age-related macular degeneration
  • Alternative splicing
  • Complement pathway
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Metal-binding
  • Reference proteome
  • Repeat
  • Secreted
  • Serine protease
  • Signal
  • Sushi
Gene Ontology (GO)
Displaying all 2 entries
GO Term
serine-type endopeptidase activity
metal ion binding
Annotation information from UniProt.
Sequence
MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGMETMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLDVDWRELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRSKVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 9 entries
Position Description PubMed ID GlyTouCan ID Source
29 N-linked (GlcNAc...) asparagine
112 N-linked (GlcNAc...) asparagine
290 N-linked (GlcNAc...) asparagine
333 N-linked (GlcNAc...) asparagine
467 N-linked (GlcNAc...) asparagine
471 N-linked (GlcNAc...) asparagine
621 N-linked (GlcNAc...) asparagine
651 N-linked (GlcNAc...) (complex) asparagine
703
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 3 entries
Pathway Name Organism
Activation of C3 and C5 Homo sapiens
Initial triggering of complement Homo sapiens
Regulation of Complement cascade Homo sapiens
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024