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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Complement component C8 alpha chain
Summary
- UniProt ID
- P07357
- Gene Symbol
-
- C8A
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011419
- GlyConnect
- GlyGen
- P07357
- PubChem
- P07357
Annotation
- Keyword
-
- 3D-structure
- Cell membrane
- Cleavage on pair of basic residues
- Complement alternate pathway
- Direct protein sequencing
- Disulfide bond
- EGF-like domain
- Glycoprotein
- Membrane attack complex
- Reference proteome
- Repeat
- Secreted
- Signal
- Transmembrane beta strand
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| extracellular space |
| plasma membrane |
| membrane |
| membrane attack complex |
| extracellular exosome |
| blood microparticle |
| GO Term |
|---|
| complement binding |
| protein-containing complex binding |
- Site Annotations
| Position | Description |
|---|---|
| 43 | Not glycosylated |
Sequence
MFAVVFFILSLMTCQPGVTAQEKVNQRVRRAATPAAVTCQLSNWSEWTDCFPCQDKKYRHRSLLQPNKFGGTICSGDIWDQASCSSSTTCVRQAQCGQDFQCKETGRCLKRHLVCNGDQDCLDGSDEDDCEDVRAIDEDCSQYEPIPGSQKAALGYNILTQEDAQSVYDASYYGGQCETVYNGEWRELRYDSTCERLYYGDDEKYFRKPYNFLKYHFEALADTGISSEFYDNANDLLSKVKKDKSDSFGVTIGIGPAGSPLLVGVGVSHSQDTSFLNELNKYNEKKFIFTRIFTKVQTAHFKMRKDDIMLDEGMLQSLMELPDQYNYGMYAKFINDYGTHYITSGSMGGIYEYILVIDKAKMESLGITSRDITTCFGGSLGIQYEDKINVGGGLSGDHCKKFGGGKTERARKAMAVEDIISRVRGGSSGWSGGLAQNRSTITYRSWGRSLKYNPVVIDFEMQPIHEVLRHTSLGPLEAKRQNLRRALDQYLMEFNACRCGPCFNNGVPILEGTSCRCQCRLGSLGAACEQTQTEGAKADGSWSCWSSWSVCRAGIQERRRECDNPAPQNGGASCPGRKVQTQAC
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 33 |
|
|
||
| 43 |
|
|||
| 44 | C-linked (Man) tryptophan |
|
||
| 437 | N-linked (GlcNAc...) asparagine | |||
| 542 | C-linked (Man) tryptophan |
|
||
| 545 | C-linked (Man) tryptophan |
|
||
| 548 | C-linked (Man) tryptophan |
|
G08918WF
G00912UN
G45395BF
G40574BA
G48414YA
G27126ED
G27058EU
G72747WU
G70619PT
G06356OH
G59626AS
G10486CT
G50045TK
G95865ZB
G57776ZU
G28681TP
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Regulation of Complement cascade | Homo sapiens |
| Terminal pathway of complement | Homo sapiens |
