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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Platelet glycoprotein Ib alpha chain
Summary
- UniProt ID
- P07359
- Gene Symbol
-
- GP1BA
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Bernard Soulier syndrome
- Cell adhesion
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Leucine-rich repeat
- Phosphoprotein
- Reference proteome
- Repeat
- Signal
- Sulfation
- Transmembrane helix
- von Willebrand disease
- Gene Ontology (GO)
| GO Term |
|---|
| fibrinolysis |
| positive regulation of leukocyte tethering or rolling |
| GO Term |
|---|
| membrane |
| extracellular exosome |
| glycoprotein Ib-IX-V complex |
| extracellular space |
| plasma membrane |
| extracellular matrix |
| external side of plasma membrane |
| cell surface |
| GO Term |
|---|
| thrombin-activated receptor activity |
Sequence
MPLLLLLLLLPSPLHPHPICEVSKVASHLEVNCDKRNLTALPPDLPKDTTILHLSENLLYTFSLATLMPYTRLTQLNLDRCELTKLQVDGTLPVLGTLDLSHNQLQSLPLLGQTLPALTVLDVSFNRLTSLPLGALRGLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLANNNLTELPAGLLNGLENLDTLLLQENSLYTIPKGFFGSHLLPFAFLHGNPWLCNCEILYFRRWLQDNAENVYVWKQGVDVKAMTSNVASVQCDNSDKFPVYKYPGKGCPTLGDEGDTDLYDYYPEEDTEGDKVRATRTVVKFPTKAHTTPWGLFYSWSTASLDSQMPSSLHPTQESTKEQTTFPPRWTPNFTLHMESITFSKTPKSTTEPTPSPTTSEPVPEPAPNMTTLEPTPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTPIPTIATSPTILVSATSLITPKSTFLTTTKPVSLLESTKKTIPELDQPPKLRGVLQGHLESSRNDPFLHPDFCCLLPLGFYVLGLFWLLFASVVLILLLSWVGHVKPQALDSGQGAALTTATQTTHLELQRGRQVTVPRAWLLFLRGSLPTFRSSLFLWVRPNGRVGPLVAGRRPSALSQGRGQDLLSTVSIRYSGHSL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 457 | O-linked (GalNAc...) threonine |
|
||
| 460 | O-linked (GalNAc...) threonine |
|
||
| 461 | O-linked (GalNAc...) serine |
|
||
| 463 | O-linked (GalNAc...) threonine |
|
||
| 467 | O-linked (GalNAc...) serine |
|
||
| 469 | O-linked (GalNAc...) threonine |
|
||
| 473 | O-linked (GalNAc...) threonine |
|
||
| 477 | O-linked (GalNAc...) threonine |
|
||
| 480 | O-linked (GalNAc...) threonine |
|
||
| 481 | O-linked (GalNAc...) threonine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Defective F9 activation | Homo sapiens |
| Defective binding of VWF variant to GPIb:IX:V | Homo sapiens |
| Enhanced binding of GP1BA variant to VWF multimer:collagen | Homo sapiens |
| GP1b-IX-V activation signalling | Homo sapiens |
| Intrinsic Pathway of Fibrin Clot Formation | Homo sapiens |
| Platelet Adhesion to exposed collagen | Homo sapiens |
| Platelet Aggregation (Plug Formation) | Homo sapiens |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | Homo sapiens |
