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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Prosaposin
Summary
- UniProt ID
- P07602
- Gene Symbol
-
- PSAP
- GLBA
- SAP1
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011421
- GlyConnect
- GlyGen
- P07602
- PubChem
- P07602
- The Human Metabolome Database
- HMDBP01673
- The O-GlcNAc Database
- P07602
- RaftProt
- P07602
- O-GlcNAcAtlas
- P07602
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Gangliosidosis
- Gaucher disease
- Glycoprotein
- Lysosome
- Metachromatic leukodystrophy
- Neurodegeneration
- Parkinson disease
- Parkinsonism
- Reference proteome
- Repeat
- Secreted
- Signal
- Sphingolipid metabolism
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| extracellular space |
| lysosome |
| lysosomal membrane |
| plasma membrane |
| intracellular membrane-bounded organelle |
| collagen-containing extracellular matrix |
| azurophil granule membrane |
| extracellular exosome |
| late endosome |
- Site Annotations
| Position | Description |
|---|---|
| 215 | Not glycosylated; in variant MLDSAPB Ile-217 |
Sequence
MYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLLYPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWN
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 426 | N-linked (GlcNAc...) asparagine | |||
| 427 |
|
|||
|
|
|
G40834TG
G37412TK
G54612UD
G63041LO
G62894KT
G11870QZ
G36191CD
G72735IY
G05724UK
G33609NS
G39188ZX
G41247ZX
G80966KZ
G25637MV
G06110VR
G00406II
G74724QE
G82348BZ
G14669DU
G49108TO
G63889NK
G90093AU
G18938DW
G47012YE
G45359RY
G72797UR
G86357DX
G20425TQ
G29857RC
G79809MM
G26145IL
G45187EI
G54702KT
G61792ET
G91636VS
G04483SK
G07695ZT
G23863VK
G42264OV
G52428MJ
G78059CC
G14260UH
G20030CU
G93500PH
G23432EQ
G43299SD
G10256JP
G61207RZ
G00986YT
G03216SJ
G28347RJ
G43664YB
G50045TK
G31936TA
G34527RW
G59471TH
G11254FL
G25381UC
G61330YQ
G66937TJ
G81295CK
G81397LO
G83006TR
G89993FE
G49874UX
G80858MF
G04744XB
G12398HZ
G29880MM
G33734YD
G61334IA
G30633FJ
G39213VZ
G42679AH
G98140IX
G23453IV
G28663KH
G39602UU
G56269EA
G69411IG
G11994QC
G45036WQ
G61884GF
G94854LT
G55220VL
G29905OR
G60145BJ
G64481DJ
G85041WE
G96771UL
G09724ZC
G66538GV
G10756ZZ
G22768VO
G00395TQ
G31685JQ
G22573RC
G63628AV
G22355FZ
G32152BH
G15407YE
G32550BI
G42666HT
G71838YU
G64581RP
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| G alpha (i) signalling events | Homo sapiens |
| Glycosphingolipid catabolism | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
| Peptide ligand-binding receptors | Homo sapiens |
| Platelet degranulation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110593 | autosomal dominant nonsyndromic deafness 9 | |
| DOID:0110720 | neuronal ceroid lipofuscinosis 4 | |
| DOID:0110721 | neuronal ceroid lipofuscinosis 1 | |
| DOID:0110722 | neuronal ceroid lipofuscinosis 7 | |
| DOID:0110723 | neuronal ceroid lipofuscinosis 8 | |
| DOID:0110724 | neuronal ceroid lipofuscinosis 8 northern epilepsy variant | |
| DOID:0110725 | neuronal ceroid lipofuscinosis 10 | |
| DOID:0110726 | neuronal ceroid lipofuscinosis 2 | |
| DOID:0110727 | neuronal ceroid lipofuscinosis 13 | |
| DOID:0110728 | neuronal ceroid lipofuscinosis 5 |
