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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Integrin alpha-IIb
Summary
- UniProt ID
- P08514
- Gene Symbol
-
- ITGA2B
- GP2B
- ITGAB
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P08514
- PubChem
- P08514
- The Human Metabolome Database
- HMDBP02103
- RaftProt
- P08514
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Calcium
- Cell adhesion
- Cleavage on pair of basic residues
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Integrin
- Metal-binding
- Pyrrolidone carboxylic acid
- Receptor
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| plasma membrane |
| extracellular exosome |
| platelet alpha granule membrane |
| focal adhesion |
| integrin complex |
| external side of plasma membrane |
| cell surface |
| blood microparticle |
| GO Term |
|---|
| metal ion binding |
| extracellular matrix binding |
| molecular adaptor activity |
| fibrinogen binding |
| identical protein binding |
| integrin binding |
Sequence
MARALCPLQALWLLEWVLLLLGPCAAPPAWALNLDPVQLTFYAGPNGSQFGFSLDFHKDSHGRVAIVVGAPRTLGPSQEETGGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKARQGLGASVVSWSDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRIYVENDFSWDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPVADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVAVGEFDGDLNTTEYVVGAPTWSWTLGAVEILDSYYQRLHRLRGEQMASYFGHSVAVTDVNGDGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQPRGPHALGAPSLLLTGTQLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLRSRPSQVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQPVVKASVQLLVQDSLNPAVKSCVLPQTKTPVSCFNIQMCVGATGHNIPQKLSLNAELQLDRQKPRQGRRVLLLGSQQAGTTLNLDLGGKHSPICHTTMAFLRDEADFRDKLSPIVLSLNVSLPPTEAGMAPAVVLHGDTHVQEQTRIVLDCGEDDVCVPQLQLTASVTGSPLLVGADNVLELQMDAANEGEGAYEAELAVHLPQGAHYMRALSNVEGFERLICNQKKENETRVVLCELGNPMKKNAQIGIAMLVSVGNLEEAGESVSFQLQIRSKNSQNPNSKIVLLDVPVRAEAQVELRGNSFPASLVVAAEEGEREQNSLDSWGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQPSDLLYILDIQPQGGLQCFPQPPVNPLKVDWGLPIPSPSPIHPAHHKRDRRQIFLPEPEQPSRLQDPVLVSCDSAPCTVVQCDLQEMARGQRAMVTVLAFLWLPSLYQRPLDQFVLQSHAWFNVSSLPYAVPPLSLPRGEAQVWTQLLRALEERAIPIWWVLVGVLGGLLLLTILVLAMWKVGFFKRNRPPLEEDDEEGE
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 46 | N-linked (GlcNAc...) asparagine |
|
||
| 280 | N-linked (GlcNAc...) asparagine |
|
||
| 601 | N-linked (GlcNAc...) asparagine |
|
||
| 603 |
|
|
||
| 711 | N-linked (GlcNAc...) asparagine |
|
||
| 874 |
|
|
||
| 876 |
|
|||
| 878 | O-linked (GalNAc...) serine | |||
| 962 |
|
|
G53434XO
G58001LT
G43417UB
G29068FM
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| ECM proteoglycans | Homo sapiens |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | Homo sapiens |
| Integrin cell surface interactions | Homo sapiens |
| Integrin signaling | Homo sapiens |
| MAP2K and MAPK activation | Homo sapiens |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | Homo sapiens |
| Platelet degranulation | Homo sapiens |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | Homo sapiens |
| Signal transduction by L1 | Homo sapiens |
| Signaling by BRAF and RAF1 fusions | Homo sapiens |
