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Receptor-type tyrosine-protein phosphatase C

Summary

UniProt ID

P08575

Gene Symbol

PTPRC
CD45

Organism

Homo sapiens (human)

External Links

GlyConnect

GlyGen

P08575

PubChem

P08575

The Human Metabolome Database

HMDBP02584

The O-GlcNAc Database

P08575

RaftProt

P08575

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disease variant
Glycoprotein
Host-virus interaction
Phosphoprotein
Protein phosphatase
Reference proteome
Repeat
SCID
Signal
Synapse
Transmembrane helix

Gene Ontology (GO)

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GO Term
natural killer cell differentiation
negative regulation of T cell mediated cytotoxicity
positive regulation of T cell mediated cytotoxicity
negative regulation of cytokine-mediated signaling pathway
hematopoietic progenitor cell differentiation
positive regulation of immunoglobulin production
negative regulation of protein kinase activity
leukocyte cell-cell adhesion
cell surface receptor signaling pathway
regulation of gene expression

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GO Term
plasma membrane
membrane
secretory granule membrane
bleb
extracellular exosome
membrane raft
membrane microdomain
focal adhesion
external side of plasma membrane
cytoplasmic side of plasma membrane

Displaying **all 8** entries
GO Term
signaling receptor binding
heparin binding
protein kinase binding
ankyrin binding
spectrin binding
heparan sulfate proteoglycan binding
protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity

Annotation information from UniProt.

Sequence

MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	GlyTouCan ID	Source
80	N-linked (GlcNAc...) asparagine		UniProt GlyGen
92	N-linked (GlcNAc...) asparagine		UniProt GlyGen
97	N-linked (GlcNAc...) asparagine		UniProt GlyGen
134		G57321FI	GlyGen
167		G53434XO G58001LT	GlyGen
176		G43417UB	GlyGen
185		G49108TO	GlyGen The O-GlcNAc Database
186	N-linked (GlcNAc...) asparagine		UniProt GlyGen
187		G49108TO	GlyGen The O-GlcNAc Database
192	N-linked (GlcNAc...) asparagine		UniProt GlyGen