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MIRAGE
Amyloid-beta precursor protein
Summary
- UniProt ID
- P08592
- Gene Symbol
-
- A4
- AD1
- App
- Gene ID
- 54226
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Amyloid
- Apoptosis
- Cell adhesion
- Cell membrane
- Cell projection
- Coated pit
- Copper
- Cytoplasm
- Cytoplasmic vesicle
- Direct protein sequencing
- Disulfide bond
- Endocytosis
- Endoplasmic reticulum
- Endosome
- Golgi apparatus
- Heparin-binding
- Iron
- Isopeptide bond
- Metal-binding
- Notch signaling pathway
- Nucleus
- Phosphoprotein
- Proteoglycan
- Reference proteome
- Secreted
- Serine protease inhibitor
- Signal
- Sulfation
- Transmembrane helix
- Ubl conjugation
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| amyloid-beta complex |
| extracellular space |
| cytoplasm |
| lysosome |
| plasma membrane |
| cell-cell junction |
| membrane |
| axon |
| dendrite |
| cytoplasmic vesicle |
| GO Term |
|---|
| gene expression |
| mitotic cell cycle |
| regulation of translation |
| endocytosis |
| cell adhesion |
| central nervous system development |
| learning or memory |
| mating behavior |
| locomotory behavior |
| negative regulation of cell population proliferation |
Sequence
MLPSLALLLLAAWTVRALEVPTDGNAGLLAEPQIAMFCGKLNMHMNVQNGKWESDPSGTKTCIGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDSIDSADAEEDDSDVWWGGADTDYADGGEDKVVEVAEEEEVADVEEEEAEDDEDVEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSVSSQSLLKTTSEPLPQDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPHHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHPFGVDSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Advanced glycosylation endproduct receptor signaling | Rattus norvegicus |
| Formyl peptide receptors bind formyl peptides and many other ligands | Rattus norvegicus |
| G alpha (i) signalling events | Rattus norvegicus |
| G alpha (q) signalling events | Rattus norvegicus |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | Rattus norvegicus |
| Lysosome Vesicle Biogenesis | Rattus norvegicus |
| Mitochondrial protein degradation | Rattus norvegicus |
| Platelet degranulation | Rattus norvegicus |
| Post-translational protein phosphorylation | Rattus norvegicus |
| Regulation of IGF Activity by IGFBP | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10652 | Alzheimer's disease |
