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5-hydroxytryptamine receptor 2C

Summary

UniProt ID

P08909

Gene Symbol

5ht1c
Htr1c
Htr2c

Gene ID

25187

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P08909
Re-Glyco: P08909

Annotation

Keyword

3D-structure
Behavior
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying **all 6** entries
GO Term
plasma membrane
dendrite
synapse
external side of plasma membrane
cell surface
G protein-coupled serotonin receptor complex

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 28 in total

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GO Term
response to xenobiotic stimulus
animal organ regeneration
positive regulation of calcium-mediated signaling
release of sequestered calcium ion into cytosol
positive regulation of ERK1 and ERK2 cascade
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
phospholipase C-activating G protein-coupled receptor signaling pathway
serotonin receptor signaling pathway
intracellular calcium ion homeostasis
chemical synaptic transmission

Displaying **all 7** entries
GO Term
Gq/11-coupled serotonin receptor activity
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
serotonin receptor activity
neurotransmitter receptor activity
identical protein binding
G protein-coupled serotonin receptor activity
serotonin binding

Annotation information from UniProt.

Sequence

MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	Source
39	N-linked (GlcNAc...) asparagine
204	N-linked (GlcNAc...) asparagine	UniProt
205	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
G alpha (q) signalling events	Rattus norvegicus
Serotonin receptors	Rattus norvegicus

Disease

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0050742	nicotine dependence	Alliance of Genome Resources
DOID:1470	major depressive disorder	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:2030	anxiety disorder	Alliance of Genome Resources
DOID:303	substance-related disorder	Alliance of Genome Resources
DOID:809	cocaine abuse	Alliance of Genome Resources
DOID:9975	cocaine dependence	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements