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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Lysosomal protective protein
Summary
- UniProt ID
- P10619
- Gene Symbol
-
- CTSA
- PPGB
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Carboxypeptidase
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Lysosome
- Reference proteome
- Signal
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| lysosome |
| membrane |
| intracellular membrane-bounded organelle |
| extracellular exosome |
| endoplasmic reticulum |
| azurophil granule lumen |
| lysosomal lumen |
| GO Term |
|---|
| carboxypeptidase activity |
| serine-type carboxypeptidase activity |
| enzyme activator activity |
Sequence
MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYAGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWDMCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKMEVQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 145 | N-linked (GlcNAc...) asparagine |
|
||
| 153 |
|
|
||
| 244 |
|
|
||
| 333 | N-linked (GlcNAc...) asparagine |
|
||
| 351 |
|
|
||
|
|
G99668VU
G04854VP
G92135MA
G27126ED
G25451PN
G83460ZZ
G07755XJ
G49018RC
G72747WU
G70619PT
G46503DX
G80920RR
G63041LO
G01485JJ
G02886BB
G90659AW
G77547TA
G83633GK
G62765YT
G47950XN
G47644PP
G05049YU
G28541PG
G85269DF
G05724UK
G31852PQ
G23719VF
G39188ZX
G41247ZX
G35029YA
G02815KT
G06110VR
G92050GC
G14669DU
G28681TP
G10846ZT
G40574BA
G08918WF
G00912UN
G59626AS
G08290VR
G01650EU
G23294PN
G73968GN
G65184UU
G42124LM
G45504EY
G37399XV
G72790NZ
G10486CT
G95865ZB
G49955PK
G72787SB
G39446WN
G57776ZU
G57317CE
G58001LT
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Defective NEU1 causes sialidosis | Homo sapiens |
| Glycosphingolipid catabolism | Homo sapiens |
| MHC class II antigen presentation | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
| Sialic acid metabolism | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:277 | chorioangioma | |
| DOID:0050156 | idiopathic pulmonary fibrosis | |
| DOID:0050461 | aspartylglucosaminuria | |
| DOID:0060180 | colitis | |
| DOID:0060189 | ileitis | |
| DOID:0060190 | ileocolitis | |
| DOID:0060357 | chylomicron retention disease | |
| DOID:0080199 | colorectal carcinoma | |
| DOID:0080334 | aortic valve disease 2 | |
| DOID:0080502 | GM1 gangliosidosis type 1 |
