MHC class II antigen presentation

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
HLA II beta chainMHC II alpha beta heterodimerHLA II alpha chainInvariant chain trimeralpha beta dimer:Ii trimer:calnexinCANX2xMHC II alpha beta heterodimer:alpha beta dimer:Ii trimer:calnexin2xMHC II alpha beta heterodimer:alpha beta dimer:Ii trimerCOPIINonameric complex in COPII vesicleNonameric complexNonameric complexNonameric complexDynaminAP-1 Complex:Arf1-GTP:Clathrin Triskelion:Nonameric complexClathrin TriskelionAP-1 ComplexArf1-GTPPiArf1-GDPAP-1 Clathrin coated nonameric complexTGN-lysosome vesicle with nonameric complexGTPGDPNonameric complexMHC class II alpha/beta/Ii nonamerMHC class II alpha/beta/Ii nonamerClathrin:AP-2 complexClathrin coated MHC class II alpha/beta/Ii nonamerClathrin coated MHC class II alpha/beta/Ii nonamerH2OSH3GL2Clathrin:AP2 complexNonameric complexSH3GL2MHC II:lip22 nonamerMHC II:lip10 nonamerMHC II:CLIPpeptide free MHC II:HLA-DMHLA-DM/HLA-DOCLIPAntigenAntigenunfolded antigenMHC class II epitopespeptide loaded MHC class IIRAB7:RILP:ORP1L complexDynein:Dynactin:microtubuleSPTBN2ARP-1Kinesins:Dynactin:microtubuleADPpeptide loaded MHC class IIATPMHC class II alpha/beta dimerLAG3:MHC IILAG3
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 78 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O00139 Kinesin-like protein KIF2A
  • KIF2
  • KIF2A
  • KNS2
view
O14576 Cytoplasmic dynein 1 intermediate chain 1
  • DNCI1
  • DNCIC1
  • DYNC1I1
view
O14782 Kinesin-like protein KIF3C
  • KIF3C
view
O15020 Spectrin beta chain, non-erythrocytic 2
  • KIAA0302
  • SCA5
  • SPTBN2
view
O43237 Cytoplasmic dynein 1 light intermediate chain 2
  • DNCLI2
  • DYNC1LI2
  • LIC2
view
O60911 Cathepsin L2
  • CATL2
  • CTSL2
  • CTSU
  • CTSV
view
O94855 Protein transport protein Sec24D
  • KIAA0755
  • SEC24D
view
O94973 AP-2 complex subunit alpha-2
  • ADTAB
  • AP2A2
  • CLAPA2
  • HIP9
  • HYPJ
  • KIAA0899
view
O94979 Protein transport protein Sec31A
  • KIAA0905
  • SEC31A
  • SEC31L1
view
O95239 Chromosome-associated kinesin KIF4A
  • KIF4
  • KIF4A
view
Displaying all 3 entries
GlyCosmos Lectin UniProt ID Lectin Name Pathway Viewer
GL_000249 P27824 Calnexin view
GL_002758 P01911 HLA class II histocompatibility antigen, DRB1 beta chain view
GL_002832 P01903 HLA class II histocompatibility antigen, DR alpha chain view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025