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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
T-cell-specific surface glycoprotein CD28
Summary
- UniProt ID
- P10747
- Gene Symbol
-
- CD28
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell membrane
- Disulfide bond
- Glycoprotein
- Immunoglobulin domain
- Phosphoprotein
- Reference proteome
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| protein complex involved in cell adhesion |
| cytosol |
| immunological synapse |
| external side of plasma membrane |
| cell surface |
| plasma membrane |
| GO Term |
|---|
| protease binding |
| protein kinase binding |
| identical protein binding |
| coreceptor activity |
Sequence
MLRLLLALNLFPSIQVTGNKILVKQSPMLVAYDNAVNLSCKYSYNLFSREFRASLHKGLDSAVEVCVVYGNYSQQLQVYSKTGFNCDGKLGNESVTFYLQNLYVNQTDIYFCKIEVMYPPPYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKPFWVLVVVGGVLACYSLLVTVAFIIFWVRSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 37 | N-linked (GlcNAc...) asparagine |
|
||
| 71 | N-linked (GlcNAc...) asparagine |
|
||
| 92 | N-linked (GlcNAc...) asparagine |
|
||
| 105 | N-linked (GlcNAc...) asparagine |
|
||
| 129 | N-linked (GlcNAc...) asparagine |
G27058EU
G59626AS
G31852PQ
G41247ZX
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| CD28 co-stimulation | Homo sapiens |
| CD28 dependent PI3K/Akt signaling | Homo sapiens |
| CD28 dependent Vav1 pathway | Homo sapiens |
| Constitutive Signaling by Aberrant PI3K in Cancer | Homo sapiens |
| Nef mediated downregulation of CD28 cell surface expression | Homo sapiens |
| PI3K/AKT Signaling | Homo sapiens |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | Homo sapiens |
