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T-cell-specific surface glycoprotein CD28

Summary

UniProt ID

P10747

Gene Symbol

CD28

Gene ID

940

Organism

Homo sapiens (human)

External Links

GlyGen: P10747
PubChem: P10747
RaftProt: P10747
Re-Glyco: P10747

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Phosphoprotein
Reference proteome
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying **all 6** entries
GO Term
plasma membrane
cytosol
external side of plasma membrane
cell surface
protein complex involved in cell adhesion
immunological synapse

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 28 in total

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GO Term
positive regulation of inflammatory response to antigenic stimulus
CD4-positive, alpha-beta T cell proliferation
negative thymic T cell selection
regulation of regulatory T cell differentiation
positive regulation of isotype switching to IgG isotypes
positive regulation of CD4-positive, alpha-beta T cell proliferation
phosphatidylinositol 3-kinase/protein kinase B signal transduction
positive regulation of cytokine production
humoral immune response
cell surface receptor signaling pathway

Displaying **all 3** entries
GO Term
coreceptor activity
protein kinase binding
identical protein binding

Annotation information from UniProt.

Sequence

MLRLLLALNLFPSIQVTGNKILVKQSPMLVAYDNAVNLSCKYSYNLFSREFRASLHKGLDSAVEVCVVYGNYSQQLQVYSKTGFNCDGKLGNESVTFYLQNLYVNQTDIYFCKIEVMYPPPYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKPFWVLVVVGGVLACYSLLVTVAFIIFWVRSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
37	N-linked (GlcNAc...) asparagine	15696168		UniProt GlyGen
71	N-linked (GlcNAc...) asparagine	19349973		UniProt GlyGen
92	N-linked (GlcNAc...) asparagine			UniProt GlyGen
105	N-linked (GlcNAc...) asparagine	15696168		UniProt GlyGen
129	N-linked (GlcNAc...) asparagine	19349973	G27058EU G59626AS G31852PQ G41247ZX	UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
CD28 co-stimulation	Homo sapiens
CD28 dependent PI3K/Akt signaling	Homo sapiens
CD28 dependent Vav1 pathway	Homo sapiens
Constitutive Signaling by Aberrant PI3K in Cancer	Homo sapiens
Nef mediated downregulation of CD28 cell surface expression	Homo sapiens
PI3K/AKT Signaling	Homo sapiens
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Homo sapiens