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MIRAGE
Hepatic triacylglycerol lipase

Summary
UniProt ID
P11150
Gene Symbol
  • HTGL
  • LIPC
Gene ID
3990
Organism
Homo sapiens (human)
GlyGen
P11150
PubChem
P11150
SwissLipids
The Human Metabolome Database
HMDBP00226
Re-Glyco
P11150
Annotation
Keyword
  • Direct protein sequencing
  • Disease variant
  • Glycoprotein
  • HDL
  • Heparin-binding
  • Hydrolase
  • Lipid degradation
  • Reference proteome
  • Secreted
  • Signal
Gene Ontology (GO)
Displaying all 4 entries
GO Term
extracellular region
extracellular space
endoplasmic reticulum lumen
high-density lipoprotein particle
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MDTSPLCFSILLVLCIFIQSSALGQSLKPEPFGRRAQAVETNKTLHEMKTRFLLFGETNQGCQIRINHPDTLQECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQPAQPVNVGLVDWITLAHDHYTIAVRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYSLGAHVSGFAGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSVGIKQPIGHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLHAGTQSMAYPCGDMNSFSQGLCLSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRAQSPFKVYHYQFKIQFINQTETPIQTTFTMSLLGTKEKMQKIPITLGKGIASNKTYSFLITLDVDIGELIMIKFKWENSAVWANVWDTVQTIIPWSTGPRHSGLVLKTIRVKAGETQQRMTFCSENTDDLLLRPTQEKIFVKCEIKSKTSKRKIR
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 4 entries
Position Description PubMed ID GlyTouCan ID Source
42 N-linked (GlcNAc...) asparagine
78 N-linked (GlcNAc...) asparagine
362 N-linked (GlcNAc...) asparagine
397 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 2 entries
Pathway Name Organism
Assembly of active LPL and LIPC lipase complexes Homo sapiens
Chylomicron clearance Homo sapiens
Disease
Displaying all 6 entries
DO ID Disease Name Source
DOID:10652 Alzheimer's disease
DOID:13809 familial combined hyperlipidemia
DOID:3393 coronary artery disease
DOID:341 peripheral vascular disease
DOID:557 kidney disease
DOID:9352 type 2 diabetes mellitus
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025