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Hepatic triacylglycerol lipase

Summary

UniProt ID

P11150

Gene Symbol

LIPC
HTGL

Organism

Homo sapiens (human)

External Links

PubChem

P11150

SwissLipids

SLP:000000569

The Human Metabolome Database

HMDBP00226

Annotation

Keyword

Direct protein sequencing
Disease variant
Glycoprotein
HDL
Heparin-binding
Hydrolase
Lipid degradation
Reference proteome
Secreted
Signal

Gene Ontology (GO)

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GO Term
fatty acid biosynthetic process
reverse cholesterol transport
cholesterol metabolic process
cholesterol homeostasis
triglyceride catabolic process
very-low-density lipoprotein particle remodeling
phosphatidylcholine catabolic process
intermediate-density lipoprotein particle remodeling
low-density lipoprotein particle remodeling
high-density lipoprotein particle remodeling

Displaying **all 4** entries
GO Term
extracellular region
extracellular space
endoplasmic reticulum lumen
high-density lipoprotein particle

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GO Term
heparin binding
apolipoprotein binding
phosphatidylserine 1-acylhydrolase activity
1-acyl-2-lysophosphatidylserine acylhydrolase activity
lipoprotein lipase activity
phospholipase activity
lysophospholipase activity
triglyceride lipase activity
phospholipase A1 activity
low-density lipoprotein particle binding

Annotation information from UniProt.

Sequence

MDTSPLCFSILLVLCIFIQSSALGQSLKPEPFGRRAQAVETNKTLHEMKTRFLLFGETNQGCQIRINHPDTLQECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQPAQPVNVGLVDWITLAHDHYTIAVRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYSLGAHVSGFAGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSVGIKQPIGHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLHAGTQSMAYPCGDMNSFSQGLCLSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRAQSPFKVYHYQFKIQFINQTETPIQTTFTMSLLGTKEKMQKIPITLGKGIASNKTYSFLITLDVDIGELIMIKFKWENSAVWANVWDTVQTIIPWSTGPRHSGLVLKTIRVKAGETQQRMTFCSENTDDLLLRPTQEKIFVKCEIKSKTSKRKIR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	Source
42	N-linked (GlcNAc...) asparagine	UniProt
78	N-linked (GlcNAc...) asparagine	UniProt
362	N-linked (GlcNAc...) asparagine	UniProt
397	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Assembly of active LPL and LIPC lipase complexes	Homo sapiens
Chylomicron clearance	Homo sapiens

Disease

Displaying entries **111 - 120** of **124** in total

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DO ID	Disease Name	Source
DOID:6713	cerebrovascular disease	DisGeNET DisGeNET
DOID:784	chronic kidney disease	DisGeNET
DOID:8543	Hodgkin's lymphoma, lymphocytic-histiocytic predominance	DisGeNET
DOID:8567	Hodgkin's lymphoma	DisGeNET
DOID:8628	Hodgkin's lymphoma, lymphocytic depletion	DisGeNET
DOID:8651	Hodgkin's granuloma	DisGeNET
DOID:8654	Hodgkin's lymphoma, mixed cellularity	DisGeNET
DOID:9080	macroglobulinemia	DisGeNET
DOID:9256	colorectal cancer	DisGeNET DisGeNET DisGeNET
DOID:9351	diabetes mellitus	DisGeNET DisGeNET

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International Collaboration

Acknowledgements