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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Pyruvate kinase PKM
Summary
- UniProt ID
- P14618
- Gene Symbol
-
- PKM
- OIP3
- PK2
- PK3
- PKM2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Acetylation
- Allosteric enzyme
- Alternative splicing
- Cytoplasm
- Direct protein sequencing
- Glycolysis
- Hydroxylation
- Isopeptide bond
- Kinase
- Magnesium
- Metal-binding
- Methylation
- Nucleus
- Phosphoprotein
- Potassium
- Pyruvate
- Reference proteome
- S-nitrosylation
- Translation regulation
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| nucleus |
| secretory granule lumen |
| mitochondrion |
| cytosol |
| rough endoplasmic reticulum |
| ficolin-1-rich granule lumen |
| extracellular region |
| cytoplasm |
| cilium |
| collagen-containing extracellular matrix |
| GO Term |
|---|
| potassium ion binding |
| protein homodimerization activity |
| pyruvate kinase activity |
| magnesium ion binding |
| transcription coactivator activity |
| mRNA binding |
| ATP binding |
| histone H3T11 kinase activity |
| RNA binding |
| protein tyrosine kinase activity |
Sequence
MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 50 |
|
|||
| 362 |
|
|||
| 365 |
|
|||
| 405 |
|
|||
| 406 |
|
|||
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Neutrophil degranulation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110892 | inflammatory bowel disease 1 | |
| DOID:0111344 | myeloproliferative disorder with eosinophilia | |
| DOID:0111503 | Li-Fraumeni syndrome 1 | |
| DOID:10223 | dermatomyositis | |
| DOID:10283 | prostate cancer | |
| DOID:10286 | prostate carcinoma | |
| DOID:10534 | stomach cancer | |
| DOID:10603 | glucose intolerance | |
| DOID:10629 | microphthalmia | |
| DOID:10652 | Alzheimer's disease |
