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5-hydroxytryptamine receptor 2A

Summary

UniProt ID

P14842

Gene Symbol

Htr2
Htr2a

Gene ID

29595

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P14842
Re-Glyco: P14842

Annotation

Keyword

3D-structure
Behavior
Cell membrane
Cell projection
Cytoplasmic vesicle
Disulfide bond
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Reference proteome
Synapse
Transmembrane helix

Gene Ontology (GO)

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GO Term
plasma membrane
axon
dendrite
cytoplasmic vesicle
neuronal cell body
postsynaptic membrane
neurofilament
caveola
presynaptic membrane
dendritic shaft

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 39 in total

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GO Term
positive regulation of glycolytic process
positive regulation of inflammatory response
detection of mechanical stimulus involved in sensory perception of pain
positive regulation of neuron apoptotic process
phospholipase C-activating serotonin receptor signaling pathway
negative regulation of synaptic transmission, glutamatergic
presynaptic modulation of chemical synaptic transmission
positive regulation of execution phase of apoptosis
positive regulation of platelet aggregation
temperature homeostasis

Displaying **all 9** entries
GO Term
G protein-coupled serotonin receptor activity
serotonin binding
Gq/11-coupled serotonin receptor activity
protein tyrosine kinase activator activity
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
serotonin receptor activity
neurotransmitter receptor activity
identical protein binding
protein-containing complex binding

Annotation information from UniProt.

Sequence

MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	Source
8	N-linked (GlcNAc...) asparagine	UniProt
38	N-linked (GlcNAc...) asparagine	UniProt
44	N-linked (GlcNAc...) asparagine	UniProt
51	N-linked (GlcNAc...) asparagine	UniProt
54	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
G alpha (q) signalling events	Rattus norvegicus
Serotonin receptors	Rattus norvegicus

Disease

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DO ID	Disease Name	Source
DOID:0050741	alcohol dependence	Alliance of Genome Resources
DOID:0050742	nicotine dependence	Alliance of Genome Resources
DOID:0060001	withdrawal disorder	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:1596	depressive disorder	Alliance of Genome Resources
DOID:2537	inflammatory and toxic neuropathy	Alliance of Genome Resources
DOID:4195	hyperglycemia	Alliance of Genome Resources
DOID:4989	pancreatitis	Alliance of Genome Resources
DOID:5419	schizophrenia	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements