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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Insulin receptor
Summary
- UniProt ID
- P15208
- Gene Symbol
-
- Insr
- Organism
- Mus musculus (house mouse)
External Links
- GlycoProtDB
- GPDB0003397
- GlyConnect
- GlyGen
- P15208
- PubChem
- P15208
- The O-GlcNAc Database
- P15208
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Cell membrane
- Cleavage on pair of basic residues
- Disulfide bond
- Endosome
- Glycoprotein
- Lysosome
- Phosphoprotein
- Receptor
- Reference proteome
- Repeat
- S-nitrosylation
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Gene Ontology (GO)
| GO Term |
|---|
| response to tumor necrosis factor |
| cellular response to growth factor stimulus |
| dendritic spine maintenance |
| amyloid-beta clearance |
| GO Term |
|---|
| caveola |
| nuclear envelope |
| lysosome |
| plasma membrane |
| insulin receptor complex |
| membrane |
| axon |
| nuclear lumen |
| dendrite membrane |
| neuronal cell body |
Sequence
MGFGRGCETTAVPLLVAVAALLVGTAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDVCPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVNFSFCQDLHFKCRNSRKPGCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCQILEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAEDSELFELDYCLKGLKLPSRTWSPPFESDDSQKHNQSEYDDSASECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRPSRKRRSLEEVGNVTATTLTLPDFPNVSSTIVPTSQEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPDERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPMGPLYASSNPEYLSASDVFPSSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFYSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGREGGSSLSIKRTYDEHIPYTHMNGGKKNGRVLTLPRSNPS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 43 | N-linked (GlcNAc...) asparagine |
|
||
| 52 | N-linked (GlcNAc...) asparagine | |||
| 105 | N-linked (GlcNAc...) asparagine | |||
| 138 | N-linked (GlcNAc...) asparagine | |||
| 242 | N-linked (GlcNAc...) asparagine | |||
| 282 | N-linked (GlcNAc...) asparagine | |||
| 322 | N-linked (GlcNAc...) asparagine |
|
||
| 364 | N-linked (GlcNAc...) asparagine | |||
| 424 | N-linked (GlcNAc...) asparagine | |||
| 445 | N-linked (GlcNAc...) asparagine |
G07755XJ
G41247ZX
G80920RR
G29545VG
G05724UK
G39188ZX
G02815KT
G06110VR
G19973ZD
G70101JE
G64527OM
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| IRS activation | Mus musculus |
| Insulin receptor recycling | Mus musculus |
| Insulin receptor signalling cascade | Mus musculus |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | Mus musculus |
| Signal attenuation | Mus musculus |
| Signaling by Insulin receptor | Mus musculus |
