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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Arylsulfatase B
Summary
- UniProt ID
- P15848
- Gene Symbol
-
- ARSB
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Calcium
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Hydrolase
- Ichthyosis
- Lysosome
- Metachromatic leukodystrophy
- Metal-binding
- Mucopolysaccharidosis
- Reference proteome
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| lysosome |
| extracellular exosome |
| endoplasmic reticulum lumen |
| cell surface |
| azurophil granule lumen |
| lysosomal lumen |
| ficolin-1-rich granule lumen |
| GO Term |
|---|
| metal ion binding |
| N-acetylgalactosamine-4-sulfatase activity |
| arylsulfatase activity |
Sequence
MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 188 | N-linked (GlcNAc...) asparagine | |||
| 190 |
|
|||
| 279 |
|
|||
| 291 | N-linked (GlcNAc...) asparagine |
|
||
| 366 | N-linked (GlcNAc...) asparagine | |||
| 426 |
|
|||
| 458 | N-linked (GlcNAc...) asparagine |
|
G90382BL
G92135MA
G00912UN
G83460ZZ
G80920RR
G62765YT
G64527OM
G31852PQ
G39188ZX
G41247ZX
G02815KT
G92050GC
G49108TO
G90659AW
G08290VR
G27947YN
G26330YA
G05724UK
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| CS/DS degradation | Homo sapiens |
| Glycosphingolipid catabolism | Homo sapiens |
| MPS VI - Maroteaux-Lamy syndrome | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
| The activation of arylsulfatases | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0111395 | mucopolysaccharidosis type IIIA | |
| DOID:10003 | sensorineural hearing loss | |
| DOID:10159 | osteonecrosis | |
| DOID:10283 | prostate cancer | |
| DOID:10286 | prostate carcinoma | |
| DOID:10581 | metachromatic leukodystrophy | |
| DOID:10588 | adrenoleukodystrophy | |
| DOID:10763 | hypertension | |
| DOID:10825 | essential hypertension | |
| DOID:10908 | hydrocephalus |
