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MIRAGE
Transforming growth factor beta-1 proprotein
Summary
- UniProt ID
- P17246
- Gene Symbol
-
- Tgfb1
- Gene ID
- 59086
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- Cleavage on pair of basic residues
- Disulfide bond
- Extracellular matrix
- Glycoprotein
- Growth factor
- Mitogen
- Reference proteome
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| microvillus |
| extracellular space |
| nucleus |
| cytoplasm |
| secretory granule |
| axon |
| extracellular matrix |
| collagen-containing extracellular matrix |
| cell surface |
| blood microparticle |
Sequence
MPPSGLRLLPLLLPLPWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESADPEPEPEADYYAKEVTRVLMVDRNNAIYDKTKDITHSIYMFFNTSDIREAVPEPPLLSRAELRLQRFKSTVEQHVELYQKYSNNSWRYLGNRLLTPTDTPEWLSFDVTGVVRQWLNQGDGIQGFRFSAHCSCDSKDNVLHVEINGISPKRRGDLGTIHDMNRPFLLLMATPLERAQHLHSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASASPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Cell surface interactions at the vascular wall | Rattus norvegicus |
| Downregulation of TGF-beta receptor signaling | Rattus norvegicus |
| Molecules associated with elastic fibres | Rattus norvegicus |
| Platelet degranulation | Rattus norvegicus |
| RUNX3 regulates CDKN1A transcription | Rattus norvegicus |
| RUNX3 regulates p14-ARF | Rattus norvegicus |
| Regulation of RUNX3 expression and activity | Rattus norvegicus |
| Syndecan interactions | Rattus norvegicus |
| TGF-beta receptor signaling activates SMADs | Rattus norvegicus |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10763 | hypertension | |
| DOID:1168 | familial hyperlipidemia | |
| DOID:3083 | chronic obstructive pulmonary disease | |
| DOID:3770 | pulmonary fibrosis | |
| DOID:576 | proteinuria |
