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Transforming growth factor beta-1 proprotein

Summary

UniProt ID

P17246

Gene Symbol

Tgfb1

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P17246

Annotation

Keyword

Cleavage on pair of basic residues
Disulfide bond
Extracellular matrix
Glycoprotein
Growth factor
Mitogen
Reference proteome
Signal

Gene Ontology (GO)

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GO Term
odontoblast differentiation
stem cell proliferation
extracellular matrix assembly
positive regulation of branching involved in ureteric bud morphogenesis
negative regulation of protein localization to plasma membrane
positive regulation of vasculature development
positive regulation of cardiac muscle cell differentiation
negative regulation of hyaluronan biosynthetic process
positive regulation of protein localization to nucleus
positive regulation of extracellular matrix assembly

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GO Term
cell surface
blood microparticle
extracellular space
cytoplasm
microvillus
secretory granule
axon
extracellular matrix
collagen-containing extracellular matrix
neuronal cell body

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GO Term
identical protein binding
cytokine activity
antigen binding
type II transforming growth factor beta receptor binding
transforming growth factor beta receptor binding
growth factor activity
type I transforming growth factor beta receptor binding
type III transforming growth factor beta receptor binding
deubiquitinase activator activity
enzyme binding

Annotation information from UniProt.

Sequence

MPPSGLRLLPLLLPLPWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESADPEPEPEADYYAKEVTRVLMVDRNNAIYDKTKDITHSIYMFFNTSDIREAVPEPPLLSRAELRLQRFKSTVEQHVELYQKYSNNSWRYLGNRLLTPTDTPEWLSFDVTGVVRQWLNQGDGIQGFRFSAHCSCDSKDNVLHVEINGISPKRRGDLGTIHDMNRPFLLLMATPLERAQHLHSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASASPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	Source
82	N-linked (GlcNAc...) asparagine	UniProt
136	N-linked (GlcNAc...) asparagine	UniProt
176	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 10** entries
Pathway Name	Organism
Cell surface interactions at the vascular wall	Rattus norvegicus
Downregulation of TGF-beta receptor signaling	Rattus norvegicus
Molecules associated with elastic fibres	Rattus norvegicus
Platelet degranulation	Rattus norvegicus
RUNX3 regulates CDKN1A transcription	Rattus norvegicus
RUNX3 regulates p14-ARF	Rattus norvegicus
Regulation of RUNX3 expression and activity	Rattus norvegicus
Syndecan interactions	Rattus norvegicus
TGF-beta receptor signaling activates SMADs	Rattus norvegicus
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Annotation

International Collaboration

Acknowledgements