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Insulin-like growth factor-binding protein 3

Summary

UniProt ID

P17936

Gene Symbol

IGFBP3
IBP3

Organism

Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011577

GlyConnect

1945

GlyGen

P17936

PubChem

P17936

The O-GlcNAc Database

P17936

Annotation

Keyword

3D-structure
Alternative splicing
Apoptosis
Direct protein sequencing
Disulfide bond
Glycoprotein
Growth factor binding
Phosphoprotein
Reference proteome
Secreted
Signal

Gene Ontology (GO)

Displaying entries **11 - 17** of 17 in total

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GO Term
type B pancreatic cell proliferation
positive regulation of myoblast differentiation
negative regulation of smooth muscle cell proliferation
regulation of insulin-like growth factor receptor signaling pathway
positive regulation of insulin-like growth factor receptor signaling pathway
MAPK cascade
positive regulation of MAPK cascade

Displaying **all 6** entries
GO Term
extracellular region
extracellular space
nucleus
insulin-like growth factor binding protein complex
endoplasmic reticulum lumen
insulin-like growth factor ternary complex

Displaying **all 6** entries
GO Term
metal ion binding
insulin-like growth factor I binding
insulin-like growth factor II binding
fibronectin binding
insulin-like growth factor binding
protein tyrosine phosphatase activator activity

Annotation information from UniProt.

Sequence

MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 18 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
116	N-linked (GlcNAc...) (complex) asparagine	19139490	G38663NM G80075MS G57776ZS G90382BL G56784JY G81263BG G34989PA G22310AV G45395BF G88374WZ G43223CG G08293MJ G27058EU G84452RH G83460ZZ G41071NU G80920RR G90659AW G62765YT G31852PQ G41247ZX G02815KT	GlycoProtDB UniProt GlyGen GlyConnect
136	N-linked (GlcNAc...) (complex) asparagine	14760718 16335952 19139490 19159218	G45395BF G48414YA G80920RR G62765YT G41247ZX	UniProt GlyGen GlyConnect
145			G57321FI	GlyGen
148			G43417UB G29068FM G57321FI	GlyGen
151			G57321FI	GlyGen
153			G57321FI	GlyGen
155			G57321FI	GlyGen
156			G57321FI	GlyGen
157			G57321FI	GlyGen
161			G57321FI	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Post-translational protein phosphorylation	Homo sapiens
Regulation of IGF Activity by IGFBP	Homo sapiens
TP53 Regulates Transcription of Death Receptors and Ligands	Homo sapiens