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Insulin-like growth factor-binding protein 3

Summary

UniProt ID

P17936

Gene Symbol

IGFBP3
IBP3

Organism

Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011577

GlyConnect

1945

GlyGen

P17936

PubChem

P17936

The O-GlcNAc Database

P17936

Annotation

Keyword

3D-structure
Alternative splicing
Apoptosis
Direct protein sequencing
Disulfide bond
Glycoprotein
Growth factor binding
Phosphoprotein
Reference proteome
Secreted
Signal

Gene Ontology (GO)

Displaying entries **1 - 10** of 17 in total

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GO Term
regulation of cell growth
osteoblast differentiation
negative regulation of protein phosphorylation
protein phosphorylation
apoptotic process
negative regulation of cell population proliferation
negative regulation of signal transduction
regulation of glucose metabolic process
negative regulation of smooth muscle cell migration
positive regulation of apoptotic process

Displaying **all 6** entries
GO Term
extracellular region
extracellular space
nucleus
insulin-like growth factor binding protein complex
endoplasmic reticulum lumen
insulin-like growth factor ternary complex

Displaying **all 6** entries
GO Term
metal ion binding
insulin-like growth factor I binding
insulin-like growth factor II binding
fibronectin binding
insulin-like growth factor binding
protein tyrosine phosphatase activator activity

Annotation information from UniProt.

Sequence

MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **11 - 18** of 18 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
186			G57321FI	GlyGen
188			G57321FI	GlyGen
192			G57321FI	GlyGen
195			G43417UB G57321FI	GlyGen
199	N-linked (GlcNAc...) (complex) asparagine	16335952 19139490	G22310AV G45395BF G88374WZ G17208MA G83460ZZ G41071NU G80920RR G90659AW G62765YT G31852PQ G41247ZX G02815KT	GlycoProtDB UniProt GlyGen GlyConnect
268			G57321FI	GlyGen
277			G57321FI	GlyGen
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Post-translational protein phosphorylation	Homo sapiens
Regulation of IGF Activity by IGFBP	Homo sapiens
TP53 Regulates Transcription of Death Receptors and Ligands	Homo sapiens