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Glutathione hydrolase 1 proenzyme

Summary

UniProt ID

P19440

Gene Symbol

GGT1
GGT

Organism

Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011591

GlyConnect

1261

GlyGen

P19440

PubChem

P19440

SwissLipids

SLP:000001454

The Human Metabolome Database

HMDBP00730

RaftProt

P19440

Annotation

Keyword

3D-structure
Acyltransferase
Alternative promoter usage
Alternative splicing
Cell membrane
Direct protein sequencing
Disease variant
Disulfide bond
Glutathione biosynthesis
Intellectual disability
Lipid metabolism
Protease
Reference proteome
Sialic acid
Signal-anchor
Transmembrane helix
Zymogen

Gene Ontology (GO)

Displaying entries **1 - 10** of 14 in total

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GO Term
zymogen activation
glutathione biosynthetic process
cysteine biosynthetic process
peptide modification
leukotriene metabolic process
glutathione catabolic process
regulation of immune system process
proteolysis
amino acid metabolic process
glutamate metabolic process

Displaying **all 3** entries
GO Term
extracellular exosome
extracellular space
plasma membrane

Displaying **all 4** entries
GO Term
leukotriene C4 gamma-glutamyl transferase activity
glutathione hydrolase activity
peptidyltransferase activity
leukotriene-C(4) hydrolase

Annotation information from UniProt.

Sequence

MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAREVAPRLAFATMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRKVLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAPLSGPVLALILNILKGYNFSRESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRAQISDDTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITTATALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAASDSRKGGEPAGY

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
95	N-linked (GlcNAc...) asparagine	20622017 24047895 26013825		UniProt GlyGen
120	N-linked (GlcNAc...) asparagine	17924658 19159218 19349973 20622017 24047895 26013825	G13910DJ G71560PC G63040RU G53075ES G12745LE G09831WQ G94665LC G89827JR G30221QT G81637OR G71463BG G65414LI G50856PC G99679NM G82443XX G32788FZ G56518TU G01160VV G80669SJ G39471UU G05962QB G38663NM G30740WO G12341GU G76417NN G70232NH G55132BD G69521XL G81124ET G03644CB G06247RL G35541EV G93718GY G13131HA G49755GI G75568BH G80075MS G29545VG G44753VC G68490OW G60834IK G86880BF G27947YN G52527GH G28622IK G90382BL G80479JV G85282JO G87123QX G79666IR G47012YE G22310AV G45395BF G07246CJ G85554PZ G40926MX G14972EH G43223CG G48414YA G87661QW G84452RH G83460ZZ G41071NU G80920RR	GlycoProtDB UniProt GlyGen GlyConnect
230	N-linked (GlcNAc...) asparagine	19159218 20622017 24047895 26013825		UniProt GlyGen
266	N-linked (GlcNAc...) asparagine	17924658 20622017 24047895 26013825		UniProt GlyGen
297	N-linked (GlcNAc...) asparagine	20622017	G37881RL G20312EM G11629QQ	GlycoProtDB UniProt GlyGen GlyConnect
344	N-linked (GlcNAc...) asparagine	17924658 20622017 24047895 26013825	G15169WU G47518TP G56784JY G82347DR G48414YA G20210JR	UniProt GlyGen GlyConnect
511	N-linked (GlcNAc...) asparagine	15084671 17924658 19159218 20622017 24047895 26013825	G12745LE G09831WQ G94665LC G89827JR G15127JD G67164EE G56770VP G11101UV G30221QT G07810QS G71463BG G65414LI G50856PC G99679NM G82443XX G95046LV G32788FZ G56518TU G63136LV G01160VV G60967DT G39471UU G05962QB G30740WO G45526EA G12341GU G15169WU G70232NH G72951AH G55132BD G37818NZ G69521XL G81124ET G06247RL G35541EV G93718GY G13131HA G49755GI G75568BH G77582RK G20312EM G80075MS G11629QQ G57776ZS G16125XL G29545VG G44753VC G68490OW G60834IK G95133RI G86795LJ G86880BF G27947YN G28622IK G80479JV G85282JO G20528HD G87123QX G96577RX G79666IR G81263BG G92135MA G98611JV G02528FI G43669FQ G45395BF G59324HL G07246CJ G85554PZ G10819WX G66163OV G40926MX G59536GA G14972EH G43223CG G00273SJ G83229XP G08918WF G71146HJ G75983OB G00912UN G49906RN G27915IV G70441OD G87661QW G83646BJ G27126ED G25451PN G27058EU G45495MK G84452RH G43769HG G83460ZZ G60033FS G41071NU G70619PT G06356OH G37868ZX G59626AS G01650EU G80920RR G73968GN G65184UU G42124LM G90659AW G59924QI G37399XV G62765YT G47644PP G72790NZ G10486CT G05049YU G72197KC G89045VA	UniProt GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
APAP ADME	Homo sapiens
Aflatoxin activation and detoxification	Homo sapiens
Defective GGT1 causes GLUTH	Homo sapiens
Defective GGT1 in aflatoxin detoxification causes GLUTH	Homo sapiens
Glutathione synthesis and recycling	Homo sapiens
LTC4-CYSLTR mediated IL4 production	Homo sapiens
Synthesis of Leukotrienes (LT) and Eoxins (EX)	Homo sapiens

Human Protein Atlas

ENSG00000100031

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Displaying entries **11 - 20** of **198** in total

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DO ID	Disease Name	Source
DOID:0050908	myelodysplastic syndrome	DisGeNET
DOID:0060058	lymphoma	DisGeNET
DOID:0060224	atrial fibrillation	DisGeNET
DOID:0060262	gallbladder disease	DisGeNET
DOID:0060449	gelatinous drop-like corneal dystrophy	DisGeNET
DOID:0070221	progressive familial intrahepatic cholestasis	DisGeNET
DOID:0070226	progressive familial intrahepatic cholestasis 1	DisGeNET
DOID:0070230	benign recurrent intrahepatic cholestasis	DisGeNET
DOID:0080144	childhood acute lymphocytic leukemia	DisGeNET
DOID:0080199	colorectal carcinoma	DisGeNET

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