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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
Summary
- UniProt ID
- P20933
- Gene Symbol
-
- AGA
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Autocatalytic cleavage
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Lysosome
- Protease
- Reference proteome
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| protein deglycosylation |
| proteolysis |
| GO Term |
|---|
| extracellular region |
| extracellular space |
| cytoplasm |
| lysosome |
| endoplasmic reticulum |
| azurophil granule lumen |
| GO Term |
|---|
| N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity |
| asparaginase activity |
| beta-aspartyl-peptidase activity |
Sequence
MARKSNLPVLLVPFLLCQALVRCSSPLPLVVNTWPFKNATEAAWRALASGGSALDAVESGCAMCEREQCDGSVGFGGSPDELGETTLDAMIMDGTTMDVGAVGDLRRIKNAIGVARKVLEHTTHTLLVGESATTFAQSMGFINEDLSTTASQALHSDWLARNCQPNYWRNVIPDPSKYCGPYKPPGILKQDIPIHKETEDDRGHDTIGMVVIHKTGHIAAGTSTNGIKFKIHGRVGDSPIPGAGAYADDTAGAAAATGNGDILMRFLPSYQAVEYMRRGEDPTIACQKVISRIQKHFPEFFGAVICANVTGSYGAACNKLSTFTQFSFMVYNSEKNQPTEEKVDCI
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 38 | N-linked (GlcNAc...) asparagine | |||
| 40 |
|
|||
| 134 |
|
|||
| 308 | N-linked (GlcNAc...) asparagine |
G80920RR
G62765YT
G31852PQ
G39188ZX
G41247ZX
G02815KT
G06110VR
G92050GC
G14669DU
G49108TO
G57321FI
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Neutrophil degranulation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10426 | Klippel-Feil syndrome | |
| DOID:10461 | dentin caries | |
| DOID:10534 | stomach cancer | |
| DOID:1059 | intellectual disability | |
| DOID:10607 | tropical sprue | |
| DOID:10608 | celiac disease | |
| DOID:10754 | otitis media | |
| DOID:10907 | microcephaly | |
| DOID:2300 | spondylolysis | |
| DOID:1094 | attention deficit hyperactivity disorder |
