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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Catechol O-methyltransferase
Summary
- UniProt ID
- P21964
- Gene Symbol
-
- COMT
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P21964
- PubChem
- P21964
- SwissLipids
- The Human Metabolome Database
- HMDBP00272
- The O-GlcNAc Database
- P21964
- RaftProt
- P21964
Annotation
- Keyword
-
- 3D-structure
- Alternative initiation
- Catecholamine metabolism
- Cell membrane
- Cytoplasm
- Direct protein sequencing
- Lipid metabolism
- Magnesium
- Metal-binding
- Methyltransferase
- Neurotransmitter degradation
- Phosphoprotein
- Reference proteome
- S-adenosyl-L-methionine
- Schizophrenia
- Signal-anchor
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| plasma membrane |
| membrane |
| axon |
| intracellular membrane-bounded organelle |
| synapse |
| dendrite |
| extracellular exosome |
| cytosol |
Sequence
MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 91 |
|
|
||
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Enzymatic degradation of Dopamine by monoamine oxidase | Homo sapiens |
| Enzymatic degradation of dopamine by COMT | Homo sapiens |
| Methylation | Homo sapiens |
| Potential therapeutics for SARS | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:12401 | intermittent explosive disorder | |
| DOID:12583 | velocardiofacial syndrome | |
| DOID:12678 | hypercalcemia | |
| DOID:12679 | nephrocalcinosis | |
| DOID:12783 | migraine without aura | |
| DOID:12849 | autistic disorder | |
| DOID:12858 | Huntington's disease | |
| DOID:1287 | cardiovascular system disease | |
| DOID:1289 | neurodegenerative disease | |
| DOID:12995 | conduct disorder |
